The Role of Adiponectin in Cardiometabolic Diseases: Effects of Nutritional Interventions

The Journal of Nutrition
Patricio López-Jaramillo

Abstract

Adiponectin is an adipocyte-derived hormone abundantly present in plasma that exerts its effects through the activation of 3 receptors. Its concentrations are negatively regulated by the accumulation of visceral fat, and clinical studies implicate hypoadiponectinemia in the pathogenesis of diabetes mellitus type 2, coronary artery disease, hypertension, and left ventricular hypertrophy. In contrast, high concentrations of adiponectin are associated with a decreased risk of coronary artery disease, with an improvement in the differentiation of preadipocytes into adipocytes, and with increased endothelial nitric oxide production. Therefore, adiponectin appears to be an important molecule involved in limiting the pathogenesis of obesity-linked disorders, and it may have potential benefits in the treatment and prevention of cardiovascular disease. Caloric restriction, moderate alcohol consumption, and consuming a Mediterranean diet increase adiponectin concentrations, and current evidence suggests a positive, dose-dependent relation between ω-3 (n-3) fatty acid intake and circulating concentrations of adiponectin. Recently, it was reported that the administration of aged garlic extract and a single food intervention with pistachios...Continue Reading

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Jul 6, 2016·Clínica e investigación en arteriosclerosis : publicación oficial de la Sociedad Española de Arteriosclerosis·Alejandra B Camargo, Walter Manucha
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Jun 5, 2019·BMC Endocrine Disorders·Salah GariballaAwad Al Essa
Mar 7, 2020·Frontiers in Endocrinology·Giuseppina Daniela NaimoSebastiano Andò
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Nov 11, 2020·Metabolic Syndrome and Related Disorders·Ewelina Pałkowska-GoździkGrzegorz Gielerak

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