PMID: 3769461Jan 1, 1986Paper

The role of adipose and hepatic tissues in the lipogenesis of the dog

Comparative Biochemistry and Physiology. B, Comparative Biochemistry
M StangassingerD Giesecke

Abstract

In order to determine the main organ of fatty acid synthesis de novo in the dog, glucose-C incorporation into fatty acids and glucose-1-C oxidation to CO2 were measured by means of glucose-U-14C and glucose-1-14C in samples of adipose and hepatic tissues of 16 animals. For comparison of the two organs the data were referred to the respective DNA content. The rate of glucose-C incorporation into fatty acids of adipose tissue exceeded that of hepatic tissue about 1000-fold. Therefore, the adipose tissue is to be considered the almost exclusive organ of lipogenesis in the adult dog. Glucose-1-C oxidation and glucose-C incorporation in adipose tissue were correlated by r = 0.887. Consequences of these results may be of concern in model experiments using dogs.

Citations

Jan 18, 2011·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Ning DingHui Li
May 15, 2008·Journal of Animal Physiology and Animal Nutrition·P NguyenH Dumon
Jan 13, 2011·Physiological Genomics·Ryan W GrantKelly S Swanson
Aug 4, 2018·Frontiers in Genetics·Bahareldin A AbdallaXiquan Zhang
Oct 20, 2018·Frontiers in Physiology·Bahareldin A AbdallaXiquan Zhang

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