The Role of Adipose Triglyceride Lipase and Cytosolic Lipolysis in Cardiac Function and Heart Failure.

Cell Reports Medicine
Ulrich KintscherRudolf Zechner

Abstract

Heart failure is one of the leading causes of death worldwide. New therapeutic concepts are urgently required to lower the burden of heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF), the two major forms of heart failure. Lipolytic processes are induced during the development of heart failure and occur in adipose tissue and multiple organs, including the heart. Increasing evidence suggests that cellular lipolysis, in particular, adipose triglyceride lipase (ATGL) activity, has an important function in cardiac (patho)physiology. This review summarizes the crucial role of cellular lipolysis for normal cardiac function and for the development of HFrEF and HFpEF. We discuss the most relevant pre-clinical studies and elaborate on the cardiac consequences of non-myocardial and myocardial lipolysis modulation. Finally, we critically analyze the therapeutic importance of pharmacological ATGL inhibition as a potential treatment option for HFrEF and/or HFpEF in the future.

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Citations

Jan 3, 2021·Progress in Lipid Research·Emeline RecazensDominique Langin
Jan 24, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kasparas PetkeviciusAntonio Vidal-Puig
Oct 4, 2021·Metabolomics : Official Journal of the Metabolomic Society·Thomas M O'ConnellR Mark Payne
Nov 21, 2021·Nature Metabolism·Gernot F GrabnerRudolf Zechner

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Methods Mentioned

BETA
biopsies

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