PMID: 2498238Jun 1, 1989Paper

The role of adjuvant irradiation following primary prostatectomy, based on histopathologic extent of tumor

International Journal of Radiation Oncology, Biology, Physics
B E ShevlinR M Shetty

Abstract

One hundred twenty-three patients who underwent primary prostatectomy at Northwestern Memorial Hospital during the-years 1976 to 1985 are reviewed. The patients were divided into three groups: Group 1 (50 patients) comprises patients with tumor well-contained within the prostate and without perineural, perivascular, or lymphatic (NVL) invasion; Group 2 (57 patients) comprises patients with more extensive tumor extending through or to the prostatic capsule, extending to or near the surgical margin, involving seminal vesicles, or having NVL invasion; Group 3 (16 patients) comprises those patients who received immediate postoperative irradiation. The actuarial 10-year local control rates of Group 1 (88%) and Group 3 (100%) were statistically superior to that of Group 2 (72%), p less than 0.05. The actuarial 10-year disease-free survival rate of Group 1 (72%) is statistically superior to that of Group 2 (56%), p less than 0.01; the difference in 10-year disease-free survival between Group 2 (56%) and Group 3 (64%) did not reach statistical significance. Ten-year actuarial survival statistics are 64%, 80%, and 76% for Groups 1, 2, and 3 respectively. There was no statistically significant difference in actuarial survival among any o...Continue Reading

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Citations

Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·S E Schild
Aug 30, 1995·International Journal of Radiation Oncology, Biology, Physics·M S AnscherR Prosnitz
Feb 1, 1996·International Journal of Radiation Oncology, Biology, Physics·S E SchildR G Ferrigni
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Oct 6, 1997·International Journal of Radiation Oncology, Biology, Physics·M J ZelefskyS A Leibel
Oct 23, 1997·International Journal of Radiation Oncology, Biology, Physics·C H CraneM D Kelly
Jan 9, 1998·International Journal of Radiation Oncology, Biology, Physics·Z PetrovichD G Skinner
Feb 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H Van PoppelE Chirpaz
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Jul 1, 1992·Postgraduate Medicine·E D Kemp
Sep 1, 1991·International Journal of Radiation Oncology, Biology, Physics·M S Anscher, L R Prosnitz

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