The role of adjuvants in therapeutic protection against paracoccidioidomycosis after immunization with the P10 peptide.

Frontiers in Microbiology
Oriana MayorgaCarlos P Taborda

Abstract

Paracoccidioidomycosis (PCM), a common chronic mycosis in Latin America, is a granulomatous systemic disease caused by the thermo-dimorphic fungus Paracoccidioides brasiliensis. The glycoprotein gp43 is the main antigen target of P. brasiliensis and a 15-mer internal peptide (QTLIAIHTLAIRYAN), known as P10, defines a major CD4(+)-specific T cell epitope. Previous results have indicated that, besides having a preventive role in conventional immunizations prior to challenge with the fungus, protective anti-fungal effects can be induced in P. brasiliensis-infected mice treated with P10 administered with complete Freund's adjuvant (CFA). The peptide elicits an IFN-γ-dependent Th1 immune response and is the main candidate for effective immunotherapy of patients with PCM, as an adjunctive approach to conventional chemotherapy. In the present study we tested the therapeutic effects of P10 combined with different adjuvants [aluminum hydroxide, CFA, flagellin, and the cationic lipid dioctadecyl-dimethylammonium bromide (DODAB)] in BALB/c mice previously infected with the P. brasiliensis Pb18 strain. Significant reductions in the number of colony forming units of the fungus were detected in lungs of mice immunized with P10 associated wit...Continue Reading

Citations

Aug 17, 2012·Human Vaccines & Immunotherapeutics·Luiz R Travassos, Carlos P Taborda
Mar 4, 2014·Current Opinion in Immunology·Som G Nanjappa, Bruce S Klein
Sep 17, 2014·Immunology and Cell Biology·Filipe M de MeloElaine G Rodrigues
Oct 16, 2015·Revista Do Instituto De Medicina Tropical De São Paulo·Carlos P TabordaL R Travassos
Nov 5, 2014·Medical Mycology·Deivys Leandro F PortuondoIracilda Z Carlos
Oct 16, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xinpeng JiangDi Liu
Jun 18, 2014·Medical Mycology·Bluma L FaintuchCarlos P Taborda
Jul 12, 2017·Mediators of Inflammation·Juliana Alves Parente-RochaMaristela Pereira
Jun 3, 2021·Journal of Fungi·Lucas Dos Santos DiasCarlos Pelleschi Taborda
May 29, 2021·Frontiers in Immunology·Leandro B R SilvaCarlos P Taborda

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