The role of ADP-ribosylation factor and SAR1 in vesicular trafficking in plants

Biochimica Et Biophysica Acta
Abdul R Memon

Abstract

Ras-like small GTP binding proteins regulate a wide variety of intracellular signalling and vesicular trafficking pathways in eukaryotic cells including plant cells. They share a common structure that operates as a molecular switch by cycling between active GTP-bound and inactive GDP-bound conformational states. The active GTP-bound state is regulated by guanine nucleotide exchange factors (GEF), which promote the exchange of GDP for GTP. The inactive GDP-bound state is promoted by GTPase-activating proteins (GAPs) which accelerate GTP hydrolysis by orders of magnitude. Two types of small GTP-binding proteins, ADP-ribosylation factor (Arf) and secretion-associated and Ras-related (Sar), are major regulators of vesicle biogenesis in intracellular traffic and are founding members of a growing family that also includes Arf-related proteins (Arp) and Arf-like (Arl) proteins. The most widely involved small GTPase in vesicular trafficking is probably Arf1, which not only controls assembly of COPI- and AP1, AP3, and AP4/clathrin-coated vesicles but also recruits other proteins to membranes, including some that may be components of further coats. Recent molecular, structural and biochemical studies have provided a wealth of detail of t...Continue Reading

References

Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S C TsaiM Vaughan
Jan 1, 1992·Methods in Enzymology·P A RandazzoR A Kahn
Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J G DonaldsonR D Klausner
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J W TamkunJ A Kennison
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·M A StamnesJ E Rothman
Jun 16, 1995·The Journal of Biological Chemistry·P A RandazzoR A Kahn
Feb 24, 1995·Science·C D'Souza-SchoreyP D Stahl
Dec 1, 1993·The Journal of Cell Biology·G TanigawaJ E Rothman
Jan 28, 1994·Science·S CockcroftJ J Hsuan
Jun 30, 1993·Biochemical and Biophysical Research Communications·A R MemonG A Thompson
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J ClarkR A Kahn
May 1, 1993·The Journal of Cell Biology·J B HelmsJ E Rothman
Mar 15, 1996·Science·R Schekman, L Orci
Mar 15, 1996·Science·P De CamilliP Novick
Apr 12, 1996·Science·J E Rothman, F T Wieland
Sep 17, 1996·Proceedings of the National Academy of Sciences of the United States of America·P P PoonG C Johnston
Sep 1, 1996·The Journal of Cell Biology·B SönnichsenG Warren
Oct 1, 1996·The Journal of Cell Biology·S I BannykhW E Balch
Nov 29, 1996·The Journal of Biological Chemistry·M Lowe, T E Kreis
Dec 5, 1996·Nature·A PeyrocheC L Jackson

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Citations

Oct 10, 2007·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Keyu GuZhongchao Yin
Oct 8, 2008·Plant Physiology·Inhwan Hwang
Oct 26, 2012·Journal of Virology·Kiwamu HyodoTetsuro Okuno
Apr 11, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Lei LuW Allan Walker
Nov 9, 2007·Traffic·Loren A MathesonFederica Brandizzi
Oct 9, 2014·Frontiers in Plant Science·Sazzad Karim, Henrik Aronsson
Dec 30, 2014·Frontiers in Plant Science·Setsuko KomatsuZahed Hossain
Aug 19, 2007·Seminars in Cell & Developmental Biology·Matthew J Paul, Lorenzo Frigerio
Dec 14, 2017·Journal of Experimental Botany·Mark KwaaitaalHans Thordal-Christensen
Nov 23, 2011·Pharmacological Reviews·Patrizia GazzerroMaurizio Bifulco
Feb 26, 2005·Journal of Cell Science·Krister WennerbergChanning J Der
Jul 23, 2009·Journal of Cell Science·Sasa StefanicAdrian B Hehl
May 1, 2021·Viruses·Rosalba Rodriguez-PeñaHernan Garcia-Ruiz
Mar 28, 2006·The American Journal of Pathology·Jeffrey J SchrickDennis S Rice
Jul 19, 2011·Current Opinion in Plant Biology·Hong-Yan Yao, Hong-Wei Xue

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