Jul 1, 1976

The role of adrenergic mechanisms in the substrate and hormonal response to insulin-induced hypoglycemia in man

The Journal of Clinical Investigation
A J GarberD M Kipnis


Sequential determinations of glucose outflow and inflow, and rates of gluconeogenesis from alanine, before, during and after insulin-induced hypoglycemia were obtained in relation to alterations in circulating epinephrine, norepinephrine, glucagon, cortisol, and growth hormone in six normal subjects. Insulin decreased the mean (+/-SEM) plasma glucose from 89+/-3 to 39+/-2 mg/dl 25 min after injection, but this decline ceased despite serum insulin levels of 153+/-22 mul/ml. Before insulin, glucose inflow and outflow were constant averaging 125.3+/-7.1 mg/kg per h. 15 min after insulin, mean glucose outflow increased threefold, but then decreased at 25 min, reaching a rate 15% less than the preinsulin rate. Glucose inflow decreased 80% 15 min after insulin, but increased at 25 min, reaching a maximum of twice the basal rate. Gluconeogenesis from alanine decreased 68% 15 min after insulin, but returned to preinsulin rates at 25 min, and remained constant for the next 25 min, after which it increased linearly. A fourfold increase in mean plasma epinephrine was found 20 min after insulin, with maximal levels 50 times basal. Plasma norepinephrine concentrations first increased significantly at 25 min after insulin, whereas significan...Continue Reading

  • References38
  • Citations141


  • References38
  • Citations141


Mentioned in this Paper

Glucagon (rDNA)
Growth Hormone Activity
Sympathetic Nervous System
Transcription Initiation
Glucose, (beta-D)-Isomer
Norepinephrine, (+, -)-Isomer
Adrenergic alpha-Agonists

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