The role of AEG-1 in the development of liver cancer

Hepatic Oncology
Chadia L RobertsonDevanand Sarkar

Abstract

AEG-1 is an oncogene that is overexpressed in all cancers, including hepatocellular carcinoma. AEG-1 plays a seminal role in promoting cancer development and progression by augmenting proliferation, invasion, metastasis, angiogenesis and chemoresistance, all hallmarks of aggressive cancer. AEG-1 mediates its oncogenic function predominantly by interacting with various protein complexes. AEG-1 acts as a scaffold protein, activating multiple protumorigenic signal transduction pathways, such as MEK/ERK, PI3K/Akt, NF-κB and Wnt/β-catenin while regulating gene expression at transcriptional, post-transcriptional and translational levels. Our recent studies document that AEG-1 is fundamentally required for activation of inflammation. A comprehensive and convincing body of data currently points to AEG-1 as an essential component critical to the onset and progression of cancer. The present review describes the current knowledge gleaned from patient and experimental studies as well as transgenic and knockout mouse models, on the impact of AEG-1 on hepatocarcinogenesis.

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Citations

Apr 22, 2017·Clinical and Experimental Pharmacology & Physiology·Yue ZhangXiuping Han
Jul 22, 2020·Technology in Cancer Research & Treatment·Jing WangJilin Cheng
Nov 9, 2017·International Journal of Urology : Official Journal of the Japanese Urological Association·Xiaoming YangDongkui Song
Jan 15, 2021·Brain Sciences·Hyun-Gug JungEun Mi Hwang
Mar 21, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lei FangWei Xu

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Methods Mentioned

BETA
surgical resection
xenograft
transgenic
immunoprecipitation assay
nuclear translocation
two-hybrid
xenografts

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