The role of afferent input in postamputation pain: a randomized, double-blind, placebo-controlled crossover study

Pain
Nina Stockfleth BuchL Nikolajsen

Abstract

In this randomized, double-blind, placebo-controlled crossover study, we investigated whether a peripheral nerve block could temporarily eliminate phantom and stump pain after amputation. Amputees with constant postamputation pain were included and randomized to receive a nerve block with lidocaine 2% with adrenaline or saline in a crossover design. Spontaneous phantom and stump pain and evoked responses were assessed at baseline and at fixed time-points until 120 minutes after lidocaine or saline injection. The primary outcome was the difference in absolute change between worst pain intensity, either phantom or stump pain, at baseline and at 30 minutes after lidocaine or saline injection. Twelve amputees were randomized and 9 patients were included in the analysis. The absolute change in median worst pain intensity between lidocaine and saline injection was -2.0 (interquartile range, -4.0 to 0.0) (n = 9, P = 0.12). Nine of 9 patients reported at least some pain relief after lidocaine injection compared with only 2 of 9 patients after saline injection (P = 0.02). Phantom pain intensity was significantly reduced after lidocaine compared with saline injection (P = 0.04), whereas there was no significant change in stump pain inten...Continue Reading

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Citations

Apr 3, 2019·Pain·Stephen G Waxman
Sep 24, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Edgar T Walters
Oct 1, 2019·Pain·Nina Stockfleth BuchLone Nikolajsen
Apr 27, 2020·European Journal of Pain : EJP·Hongcai LiuHerta Flor
Aug 9, 2020·Pain Reports·Jun-Hui YuanStephen G Waxman
Nov 2, 2016·The Cochrane Database of Systematic Reviews·Maria Jenelyn M AlviarMonalisa Dungca
Feb 11, 2020·Frontiers in Molecular Neuroscience·Jessica R YaskoRichard E Mains
Jun 26, 2020·Physiological Reviews·Nanna Brix FinnerupTroels Staehelin Jensen
Oct 29, 2020·Nature Reviews. Neurology·Matthew AlsaloumStephen G Waxman
Oct 24, 2020·Frontiers in Cellular Neuroscience·Peter A Smith
Jan 4, 2021·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Rachael MillerKerry Avery

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