The role of aldehyde oxidase in drug metabolism

Expert Opinion on Drug Metabolism & Toxicology
Enrico Garattini, Mineko Terao

Abstract

Aldehyde oxidases (AOXs) are molybdo-flavoenzymes with complex evolutionary profiles, as the number and types of active AOX genes vary according to the animal species considered. Humans and higher primates have a single functional AOX1 gene, while rodents are endowed with four AOXs. Along with the endoplasmic cytochrome P450 system (CYP450), cytoplasmic AOX1 is the major enzyme involved in the hepatic phase I metabolism of numerous xenobiotics. The authors review literature to highlight the fact that aldehydes are not the only AOX substrates, as aza- and oxo-heterocycles, that represent the scaffold of many drugs, are also oxidized efficiently by these enzymes. Additionally, the ndefine the different complements of AOX isoenzymes expressed in humans and animal models used in drug metabolism studies and discuss the implications. Furthermore, the authors report on human AOX1 allelic variants that alter the activity of this enzyme. Finally, they discuss the factors of potential importance in controlling the functional activity of AOX1. There is evidence for an increasing relevance of AOX1 in the metabolism and clearance of new drugs, as measures aiming at controlling CYP450-dependent metabolism of prospective therapeutic agents ar...Continue Reading

References

Dec 14, 1979·Biochemical and Biophysical Research Communications·S Brandänge, L Lindblom
Aug 1, 1976·Journal of Pharmaceutical Sciences·C N HodnettJ A Sabean
Dec 1, 1992·Clinical Pharmacology and Therapeutics·M V RellingW E Evans
Oct 1, 1987·European Journal of Drug Metabolism and Pharmacokinetics·C BeedhamD J Rance
Apr 30, 1984·Biochemical and Biophysical Research Communications·S Kitamura, K Tatsumi
Oct 31, 1983·Biochemical and Biophysical Research Communications·P E GormleyR Cysyk
Jun 29, 1984·Biochemical and Biophysical Research Communications·S Kitamura, K Tatsumi
Feb 9, 1994·Biochemical Pharmacology·I G Robertson, R S Gamage
Jan 1, 1994·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·D J CritchleyC Beedham
Sep 14, 1993·Biochemical Pharmacology·Y MoriwakiK Higashino
Dec 29, 1995·The Journal of Biological Chemistry·M L CalziE Garattini
Oct 1, 1996·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A A AcheampongD Tang-Liu
May 1, 1997·Biochemistry and Molecular Biology International·K SugiharaK Dohi
Aug 1, 1997·Biochemical Society Transactions·M TeraoE Garattini
Jan 27, 1998·Pharmacy World & Science : PWS·C Beedham
Jun 29, 1999·The Journal of Pharmacy and Pharmacology·C G JordanC Beedham
Nov 24, 1999·The Journal of Biological Chemistry·W AmbroziakR Pietruszko
Mar 22, 2000·Journal of Agricultural and Food Chemistry·G J Diaz, E J Squires
Mar 22, 2000·Biological & Pharmaceutical Bulletin·T KurodaM Hayashi
Sep 27, 2000·Proceedings of the National Academy of Sciences of the United States of America·C EnrothE F Pai
Jul 24, 2001·Current Drug Metabolism·S Vickers, S L Polsky
Jul 13, 2002·Trends in Biochemical Sciences·Russ Hille
Nov 7, 2002·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A B RenwickB G Lake
Jun 21, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yoshimitsu KuwabaraTakeshi Nishino
Jun 27, 2003·Journal of Clinical Psychopharmacology·Christine BeedhamR Scott Obach
Oct 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Francisco Rodríguez-TrellesFrancisco J Ayala
Dec 19, 2003·Journal of Clinical Pharmacology·R Scott ObachChristine Beedham
Jan 8, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·R Scott Obach

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Citations

Jun 20, 2012·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Ryan D MorrisonJ Scott Daniels
Sep 22, 2012·Drug Metabolism and Disposition : the Biological Fate of Chemicals·John T Barr, Jeffrey P Jones
Dec 4, 2012·International Journal of Molecular Sciences·Kimiyoshi IchidaTakeshi Nishino
Sep 24, 2013·Biochemical Pharmacology·Jianghong Fan, Inés A M de Lannoy
Jun 20, 2012·Future Medicinal Chemistry·Frederick A VillamenaKevin M Nash
Dec 25, 2012·Cellular and Molecular Life Sciences : CMLS·Mami KurosakiEnrico Garattini
Apr 10, 2013·Expert Opinion on Drug Discovery·Enrico Garattini, Mineko Terao
Dec 13, 2012·Expert Opinion on Drug Metabolism & Toxicology·James Matthew HutzlerMichael A Zientek
Jan 8, 2014·Expert Opinion on Drug Metabolism & Toxicology·Li Di
Aug 6, 2015·Clinical Pharmacokinetics·Srinivasan RamanathanBrian P Kearney
Jan 30, 2014·Journal of Medicinal Chemistry·Fionn O'HaraPhil S Baran
Dec 19, 2015·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Tomoyuki IsobeHiroyuki Kawai
Feb 28, 2016·Archives of Toxicology·Mineko TeraoEnrico Garattini
Mar 30, 2016·Journal of Biotechnology·Márcia Ferreira AntunesMargit Winkler
Sep 1, 2015·Nature Chemical Biology·Catarina CoelhoMaria João Romão
Mar 31, 2015·Journal of Clinical Pharmacology·Feng JinSrini Ramanathan
Oct 11, 2012·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Deepak DalvieSue Zhou
Oct 26, 2013·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Ramakrishna NirogiArun Kumar Manoharan
May 9, 2012·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R Scott ObachAmin M Kamel
Jan 4, 2013·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Maryam Hamzeh-MivehroudSiavoush Dastmalchi
Dec 30, 2014·Journal of Pharmacological and Toxicological Methods·Lars Dalgaard
Jan 16, 2015·ACS Medicinal Chemistry Letters·Paul A BarsantiQin Yue
Jul 6, 2014·Biochemical and Biophysical Research Communications·Majid Rasool KamliInho Choi
Oct 8, 2014·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Nuno M F S A CerqueiraMaria João Ramos
Jun 11, 2016·Organic & Biomolecular Chemistry·Alexandria P TaylorOlugbeminiyi Fadeyi
Feb 5, 2016·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Alessandro FotiSilke Leimkühler
Mar 5, 2016·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Rachel D CrouchJ Scott Daniels
Jun 15, 2016·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Robert S Foti, Deepak K Dalvie
Oct 1, 2016·Redox Report : Communications in Free Radical Research·Jun WangZhiyuan Mi
Jan 18, 2017·Expert Opinion on Drug Discovery·Mohammad-Reza Rashidi, Somaieh Soltani
Mar 11, 2017·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Rachel D CrouchJ Scott Daniels
Jul 28, 2016·Scientific Reports·Mineko TeraoEnrico Garattini
Jan 28, 2017·Current Opinion in Chemical Biology·Maria João RomãoSilke Leimkühler
Feb 7, 2017·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Zhengsheng MaoXin Di
Jun 29, 2017·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Toshito NakagawaMasaki Ishigai
Feb 24, 2018·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Austin C LiPhilmore Robertson
Mar 15, 2018·Animal Science Journal = Nihon Chikusan Gakkaihō·Keren LongXuewei Li

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