The role of aldosterone in renal sodium transport

Seminars in Nephrology
David J Rozansky

Abstract

Aldosterone is the body's major hormone involved in volume homeostasis because of its effects on sodium reabsorption in the distal nephron. Our comprehension of the signaling pathways that this mineralocorticoid unleashes has been enhanced through the convergence of bedside physiologic observations with advances in medical genetics and molecular biology. This overview updates our current understanding of the aldosterone-initiated pathways throughout the distal nephron to promote sodium retention. Three essential features of the pathways are explored: how the mineralocorticoid gains specificity and targets gene transcription in distal tubular cells; how the key endpoints of aldosterone action in these cells-the epithelial sodium channel, the thiazide-sensitive sodium chloride cotransporter, and Na,K,ATPase-are regulated; and how 3 kinases, directly or indirectly, are activated by aldosterone and serve as critical intermediaries in regulating the sodium transporters. Remarkably, perturbations in many genes integral to aldosterone-induced pathways result in blood-pressure abnormalities. The familial disorders of hypertension and hypotension that follow from these mutated genes are presented with their molecular and physiologic con...Continue Reading

References

Nov 5, 1997·The Journal of Biological Chemistry·R A ShimketsC M Canessa
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·G H KimM A Knepper
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·S Y ChenD Pearce
Jun 8, 1999·The Journal of Biological Chemistry·A Náray-Fejes-TóthG Fejes-Tóth
Sep 10, 1999·The Journal of Biological Chemistry·S EskandariE M Wright
Dec 10, 1999·The Journal of Biological Chemistry·J D StockandD C Eaton
Jan 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E KamyninaO Staub
Mar 10, 2001·Cell·R P LiftonD S Geller
Jun 26, 2001·Journal of the American Society of Nephrology : JASN·Joseph G AbdallahDavid H Ellison
Jul 18, 2001·The Journal of Clinical Investigation·X Y WangM A Knepper
Aug 11, 2001·Science·F H WilsonR P Lifton
Oct 13, 2001·The Journal of Biological Chemistry·V SummaE Féraille
Jun 1, 2002·Journal of the American Society of Nephrology : JASN·Joke C De JongRené J M Bindels
Jun 13, 2002·American Journal of Physiology. Renal Physiology·David J RozanskyDavid Pearce
Jun 28, 2002·Physiological Reviews·Stephan Kellenberger, Laurent Schild
Sep 10, 2002·American Journal of Physiology. Renal Physiology·Shyama MasilamaniMark A Knepper
Dec 20, 2002·JAMA : the Journal of the American Medical Association·UNKNOWN ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatm
Apr 3, 2003·The Journal of Clinical Investigation·Chao-Ling YangDavid H Ellison
May 24, 2003·Annals of the New York Academy of Sciences·François VerreyMarija Zecevic
Jul 10, 2003·JAMA : the Journal of the American Medical Association·Ihab Hajjar, Theodore A Kotchen
Jun 1, 1958·Archives of Disease in Childhood·D B CHEEK, J W PERRY
Nov 11, 2003·Nature Genetics·Kristopher T KahleRichard P Lifton
Jan 13, 2004·Pflügers Archiv : European journal of physiology·Marija ZecevicFrancois Verrey
May 12, 2004·Molecular and Cellular Endocrinology·P SartoratoM-C Zennaro
May 12, 2004·Molecular and Cellular Endocrinology·Ralf LöselMartin Wehling
Jun 25, 2004·The Journal of Biological Chemistry·Alexander StaruschenkoJames D Stockand
Aug 3, 2004·Pediatrics·UNKNOWN National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents
Sep 4, 2004·American Journal of Physiology. Renal Physiology·Pierre MenetonDavid G Warnock
Sep 29, 2004·The Journal of General Physiology·Diego Alvarez de la RosaCecilia M Canessa
Oct 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kristopher T KahleRichard P Lifton
Nov 5, 2004·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Allan D Struthers
Dec 4, 2004·The Journal of Biological Chemistry·Ruifeng Zhou, Peter M Snyder
Dec 8, 2004·Proceedings of the National Academy of Sciences of the United States of America·Anikó Náray-Fejes-TóthGéza Fejes-Tóth
Apr 2, 2005·Molecular Endocrinology·Laurent Pascual-Le Tallec, Marc Lombès

❮ Previous
Next ❯

Citations

Oct 2, 2009·Canadian Journal of Physiology and Pharmacology·Priscilla M C Dos SantosRicardo Fernandez
Oct 22, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Ekaterina PetrovichHaim Garty
May 25, 2011·FEBS Letters·Mentor SopjaniFlorian Lang
Jan 13, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Oded EdelheitAaron Hanukoglu
Mar 8, 2016·Mayo Clinic Proceedings·Biff F Palmer, Deborah J Clegg
Feb 6, 2007·Seminars in Nephrology·Melvin E Laski, Sandra Sabatini
Nov 15, 2013·Biology of Reproduction·Ana D Paixão, Barbara T Alexander
Nov 2, 2016·Environmental Health Perspectives·Michele A La MerrillChristoph Buettner
Apr 12, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Biff F Palmer
Aug 22, 2008·American Journal of Physiology. Renal Physiology·D C A Leite-DellovaM Mello-Aires
Jun 26, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Armin Just
Mar 5, 2008·Clinical and Experimental Nephrology·Miki Nagase, Toshiro Fujita
Apr 29, 2020·Food & Function·María Luisa OjedaOlimpia Carreras
Jul 5, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Randall D JenkinsDavid J Rozansky

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.