The role of alisertib in treatment of peripheral T-cell lymphomas

Future Oncology
Eve Gallop-Evans

Abstract

Peripheral T-cell lymphomas are aggressive lymphomas with poor outcomes for which novel treatments are urgently needed. Alisertib (MLN8237) is a second-generation oral Aurora A kinase inhibitor. Treatment with alisertib results in an accumulation of cells with abnormal mitotic spindles, leading to decreased proliferation and apoptosis in a range of human tumor cell lines. Alisertib has shown single-agent antitumor activity in animal xenograft models and promising antitumor activity alone or in combination with other agents in patients with solid and hematologic cancers, and T-cell lymphomas in particular. It is currently being tested in randomized controlled Phase III trials in relapsed/refractory peripheral T-cell lymphoma.

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Citations

Jun 9, 2017·Chemistry : a European Journal·Dong-Yao WangYi-Feng Chai

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Methods Mentioned

BETA
histone acetylation
xenograft
biopsies

Clinical Trials Mentioned

NCT01198665
NCT00646854
NCT01777152
NCT01482962
NCT01466881
NCT01897012
NCT01567709

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