The role of allopurinol on oxidative stress in experimental hyperthyroidism.

Journal of Endocrinological Investigation
O MakayE Yetkin

Abstract

During hyperthyroidism, production of free oxygen radicals derives, where xanthine oxidase may also play an important role. Allopurinol, a xanthine oxidase inhibitor, has a significant effect on thyrotoxicosis-related oxidative stress. However, the relationship between thyroid hormones, oxidative stress parameters and allopurinol remains to be explored. Forty-two Wistar albino rats were divided into three groups. Rats in group A served as negative controls, while group B had untreated thyrotoxicosis and group C received allopurinol. Hyperthyroidism was induced by daily 0.2 mg/kg L-thyroxine intraperitoneally in groups B and C; 40 mg/kg allopurinol were given daily intraperitoneally. Efficacy of the treatment was assessed after 72 h and 21 days, by measuring serum xanthine oxidase (XO), malondialdehyde (MDA), glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPx) and nitric oxide derivates (NO*x). In both time periods, serum XO, MDA, GSH and NO*x levels were significantly increased after thyroid hormone induction (p<0.05). Levels of XO, MDA and NO*x decreased with allopurinol treatment (p<0.05). There was a remarkable decrease in triiodothyronine levels in group C after 72 h (p<0.05), and in both triiodothyr...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Dec 1, 1990·The Journal of Trauma·P A Ward, G O Till
Sep 1, 1993·Journal of Cardiovascular Pharmacology·C MarchantC Sernia
Jan 1, 1994·Methods in Enzymology·D K Das, N Maulik
Jul 1, 1993·British Medical Bulletin·U Rangan, G B Bulkley
Feb 7, 1998·Hypertension·B S HenningtonJ F Reckelhoff
Jan 1, 1997·Nitric Oxide : Biology and Chemistry·V FernándezL A Videla
Dec 22, 1999·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·G BianchiG Marchesini
Jan 14, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·N Chakrabarti, A K Ray
Jun 14, 2000·American Journal of Ophthalmology·E A BouzasD A Koutras
Jan 6, 2001·Redox Report : Communications in Free Radical Research·L A Videla
Feb 12, 2002·Neuroscience and Biobehavioral Reviews·Jeremy W SmithJames W Smythe
Feb 28, 2002·Current Medicinal Chemistry·F BorgesF Roleira
Jun 29, 2002·European Journal of Endocrinology·Andrés QuesadaAntonio Osuna
Nov 7, 2002·Bioscience Reports·Fernando GogliaAntonia Lanni
Jan 11, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Ulrike ReschHelmut Sinzinger
Jan 13, 2005·American Journal of Physiology. Endocrinology and Metabolism·Isabel Rodríguez-GómezFélix Vargas
Apr 9, 2005·The Journal of Endocrinology·R M McAllisterK D Wyatt
Jul 20, 2005·Clinical and Experimental Pharmacology & Physiology·Burhanettin Baydas, Ismail Meral
Jan 4, 2006·Cellular and Molecular Life Sciences : CMLS·P Venditti, S Di Meo
Sep 25, 2007·Pediatric Surgery International·Ozer MakayOmer Ozutemiz
Dec 20, 2007·American Journal of Hypertension·Junhui ZhenXin J Zhou

❮ Previous
Next ❯

Citations

Sep 8, 2015·Rheumatology International·Fernando Perez-RuizMaria Angeles Aniel-Quiroga
Jul 7, 2015·Oxidative Medicine and Cellular Longevity·Mohammad T ElnakishPaul M L Janssen
Nov 11, 2016·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Nesreen E M MohammedAli A Abo-Saif
Aug 14, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Seong-Mo KimSae-Kwang Ku
Nov 5, 2016·The American Journal of Chinese Medicine·Sang-In ParkSae-Kwang Ku

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.