PMID: 7524435Sep 10, 1994Paper

The role of alpha 2M receptor/LRP in chylomicron remnant metabolism

Annals of the New York Academy of Sciences
U BeisiegelG Olivecrona

Abstract

A strong candidate for the long-searched CR receptor might be the alpha 2MR/LRP. Presently, we are overseeing a whole series of in vitro experiments from different laboratories that show that LRP expresses all the features for being such a receptor protein. LRP is localized on the liver cell surface, as well as on most other animal cells. It recognizes apo E-enriched lipoproteins as beta-VLDL and CR. There is evidence that CR contain LPL and it has been demonstrated that LPL binds with high affinity to LRP. This has been shown in cell binding experiments with subsequent cross-linking and in direct assays on purified receptor protein. HL, which is expressed in liver cells and localized at the liver cell surface, is also able to bind to LRP. Moreover, LRP is found in endosomes and can mediate the uptake of beta-VLDL and CR. Further studies are necessary to evaluate its role in vivo as well as its regulation. The interplay between the different ligands of this large multifunctional receptor protein needs to be clarified. It should be emphasized here that, by describing LPL as a new mediator of CR uptake in the liver and by providing evidence for a direct interaction between LPL and LRP, the role of LRP in the remnant catabolism ha...Continue Reading

References

Oct 27, 1975·Biochemical and Biophysical Research Communications·J M FeltsR T Crane
Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S TakahashiT Yamamoto
Oct 1, 1992·The Journal of Clinical Investigation·S C RumseyI J Goldberg
Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·R A OrlandoM G Farquhar
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·G BuA L Schwartz
Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·U BeisiegelG Bengtsson-Olivecrona
Feb 22, 1990·Nature·F K WinklerW Hunziker
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H LundR J Havel
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T G KirchgessnerA Andalibi
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R C KowalM S Brown
Oct 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P R GalleH Schaller
Oct 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·C H Florén
Aug 26, 1988·Science·J D EskoJ L Weinke
Apr 4, 1986·Science·M S Brown, J L Goldstein

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Citations

Dec 11, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·K W van DijkM H Hofker
Nov 12, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Vicenta Llorente-CortésLina Badimon
Sep 18, 2002·Journal of Lipid Research·Kaspar K Berneis, Ronald M Krauss
Jul 1, 1997·The Proceedings of the Nutrition Society·U Beisiegel, J Heeren
Jan 15, 1999·Atherosclerosis·H JansenK Schoonderwoerd
Jan 1, 1996·Pharmacology & Therapeutics·V MurthyC Gagne

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