The role of alpha(1)-adrenoceptors and 5-HT(1A) receptors in the control of the micturition reflex in male anaesthetized rats

British Journal of Pharmacology
R K ConleyAndrew G Ramage

Abstract

1. The effects of the alpha(1)-adrenoceptor antagonists doxazosin (0.1 -- 2 mg kg(-1)), RS-100329 (alpha(1A); 0.01 -- 1 mg kg(-1)), RS-513815 (Ro 151-3815, alpha(1B); 0.3 -- 3 mg kg(-1)) and BMY 7378 (alpha(1D); 0.1 -- 1 mg kg(-1)), the 5-HT(1A) receptor agonist, 8-OH-DPAT (0.03 -- 0.3 mg kg(-1)) and antagonist WAY-100635 (0.03 -- 0.3 mg kg(-1)) were investigated (i.v.) on the 'micturition reflex' in the urethane anaesthetized male rat. 2. Reflex-evoked urethra contractions were most sensitive to the inhibitory action of RS-100329, followed by doxazosin, BMY 7378 and WAY-100635 and then RS-513815. The maximum inhibition was 66, 63, 54, 46 and 22% at doses of 0.3, 0.5, 0.3, 0.3 and 3 mg kg(-1) respectively. 3. BMY 7378 and 8-OH-DPAT decreased, while WAY-100635 increased, the pressure threshold to induce bladder contraction. WAY-100635 (0.01 mg kg(-1)) blocked the effects of BMY 7378 (1 mg kg(-1)) on bladder pressure and volume threshold. 4. Doxazosin, RS-100329 and BMY 7378 had a similar potency in inducing a fall in arterial blood pressure while WAY-100635 only caused a fall at the highest dose. 5. Therefore, reflex-evoked urethral contraction involves the activation of alpha(1A/1D)-adrenoceptors, as BMY 7378 and RS-100329 are ...Continue Reading

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Citations

Dec 12, 2012·Naunyn-Schmiedeberg's Archives of Pharmacology·Toshiki HatanakaSeiji Kaku
Jul 26, 2002·Brain Research·Karl B ThorJohn M Schaus
Nov 2, 2002·British Journal of Pharmacology·Matthew R SkinnerDavid Jordan
Jan 1, 2010·American Journal of Physiology. Renal Physiology·Chen-Li Cheng, William C de Groat
Dec 14, 2011·Canadian Journal of Physiology and Pharmacology·Inés López-IslasJosé A Terrón
Sep 24, 2005·Autonomic & Autacoid Pharmacology·R Villalobos-MolinaI A Gallardo-Ortíz
Mar 7, 2006·Pharmacology & Therapeutics·David R Thomas
Dec 22, 2004·The Journal of Physiology·Daniel O KellettDavid Jordan
Sep 18, 2002·Japanese Journal of Pharmacology·Akira YoshidaNobuyuki Tanaka
Jul 30, 2004·The Journal of Comparative Neurology·Andrew G Ramage
Sep 13, 2007·Neurourology and Urodynamics·Phillip P SmithGeorge T Somogyi
Dec 22, 2009·Neurourology and Urodynamics·M J DrakeL Birder
Feb 9, 2006·British Journal of Pharmacology·William C de Groat
Feb 9, 2006·British Journal of Pharmacology·Martin C Michel, Wim Vrydag
Jan 6, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Paul C DolberJerome P Reiter
Apr 15, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Shih-Ching ChenChih-Wei Peng
Sep 21, 2013·American Journal of Physiology. Renal Physiology·Wen-Jia FanChih-Wei Peng
Sep 12, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Wen-Jia FanYu Ru Kou
Jul 13, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·V Julia-GuilloteauF Giuliano

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