Nov 23, 2019

The role of amiodarone in contemporary management of complex cardiac arrhythmias

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Nebojša MujovićTatjana S Potpara

Abstract

Amiodarone is an iodinated benzofuran derivative, a highly lipophilic drug with unpredictable pharmacokinetics. Although originally classified as a class III agent due to its ability to prolong refractoriness in cardiac regions and prevent/terminate re-entry, amiodarone shows antiarrhythmic properties of all four antiarrhythmic drug classes. Amiodarone is a potent coronary and peripheral vasodilator and can be safely used in patients with left ventricular dysfunction after myocardial infarction or those with congestive heart failure or hypertrophic cardiomyopathy. Its use is regularly accompanied with QT and QTc-interval prolongation but rarely with ventricular proarrhythmia. It is the most powerful pharmacological agent for long-term sinus rhythm maintenance in patients with atrial fibrillation. Amiodarone, particularly if co-administered with beta-blockers, reduces the rate of arrhythmic death due to ventricular tachyarrhythmias in patients with heart failure, but its benefit on cardiovascular and overall survival in these patients is uncertain. In addition, amiodarone is an important adjuvant drug for the reduction of shocks in patients with an implantable cardioverter-defibrillator. Over the past 40 years, amiodarone became...Continue Reading

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Mentioned in this Paper

Vasodilator [EPC]
Co-treatment
Hypertrophic Cardiomyopathy
Amiodarone
Ventricular Dysfunction, Left
Anti-Arrhythmia Agents
Myocardial Infarction
Anatomical Space Structure
Atrial Fibrillation
Pharmacologic Substance

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