The role of AMPA and metabotropic glutamate receptors on morphine withdrawal in infant rats

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
Hongbo Zhu, G A Barr

Abstract

Glutamate receptors, especially N-methyl-d-aspartate (NMDA) receptors, are hypothesized to play key roles in opiate tolerance and withdrawal. There is also accumulating evidence that alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists and group II metabotropic glutamate receptor (mGluR) agonists attenuate opiate withdrawal. However, most existing data are derived from adult animal models. Glutamate receptor types undergo dramatic developmental changes during early life. Thus, the pharmacological effects on opiate withdrawal of NMDA receptor, AMPA receptor, and mGluR antagonists in the developing organism may not be comparable to those in the adult. Indeed, NMDA receptor antagonists do not block morphine tolerance or withdrawal in the 7-day-old rat, but are partially effective in the 14-day-old, and fully effective in the 21-day-old. Thus, there is a transition period around the second post-natal week for NMDA receptor antagonists to suppress opiate tolerance and withdrawal. A combination of in vivo and in vitro assays was used in the present studies to test the effect of drugs acting on AMPA and group II mGlu receptors on morphine withdrawal in rats at 7, 14, and 21 days of age. These ages repre...Continue Reading

References

Nov 15, 1977·American Journal of Obstetrics and Gynecology·J F ConnaughtonL P Finnegan
Jul 1, 1979·The Journal of Pediatrics·J T WilsonA W Kilroy
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·S K SharmaM Nirenberg
Sep 14, 1992·Neuroscience Letters·D E Pellegrini-GiampietroR S Zukin
Jan 1, 1992·Clinical Neuropharmacology·G K AghajanianJ H Kogan
Sep 19, 1991·Brain Research. Developmental Brain Research·S E CardenM A Hofer
Jan 1, 1991·Progress in Brain Research·K Rasmussen
Apr 1, 1990·Pharmacology, Biochemistry, and Behavior·H KoyuncuoğluF Aricioğlu
Dec 20, 1974·Nature·M Otsuka, S Konishi
Feb 1, 1966·Psychological Reports·L M Geller, E H Geller
Jan 1, 1984·Annual Review of Neuroscience·D E Redmond, J H Krystal
May 1, 1995·Progress in Neurobiology·G A Kerkut, J Bagust
Aug 1, 1995·British Journal of Anaesthesia·M Fitzgerald
Jan 1, 1995·Neuropharmacology·J P Pin, R Duvoisin
Mar 1, 1994·Neurotoxicology and Teratology·G A Barr, K Jones
Jun 1, 1993·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·S L CappendijkM R Dzoljic
Jan 11, 1996·European Journal of Pharmacology·S TokuyamaI K Ho
Dec 1, 1995·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·B H HermanP Bridge
Dec 1, 1995·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·K Rasmussen
Dec 1, 1995·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·K A Trujillo
Jul 4, 1996·European Journal of Pharmacology·M I RosenT R Kosten
Nov 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·K RasmussenG K Aghajanian
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·P J Conn, J P Pin
Apr 1, 1997·Trends in Pharmacological Sciences·M J ChristieC E Bellchambers

❮ Previous
Next ❯

Citations

Aug 2, 2001·Trends in Pharmacological Sciences·H Zhu, G A Barr
Jan 5, 2006·ILAR Journal·Kimberlei A RichardsonGabrielle L McLemore
Mar 11, 2010·Behavioural Pharmacology·Scott M RawlsJae Kim
May 12, 2009·Neuroscience and Biobehavioral Reviews·Yuan GuoYan Zhao
Aug 27, 2009·Developmental Psychobiology·Anika A McPhie, Gordon A Barr
Jul 26, 2005·Peptides·Richard J Bodnar, Gad E Klein
Jul 19, 2011·Brain Research Bulletin·Siamak Shahidi, Parisa Hasanein
Nov 15, 2013·Journal of Neurochemistry·Claire J Williams, David T Dexter
Feb 18, 2017·Oncotarget·Mery Stefani Leivas PereiraDiogo Losch de Oliveira
Jan 26, 2021·Frontiers in Cell and Developmental Biology·Katherine E OdegaardSowmya V Yelamanchili
Oct 4, 2005·Cellular Signalling·Damien S K Samways, Graeme Henderson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.