PMID: 7965011Jul 1, 1994Paper

The role of an inwardly rectifying chloride conductance in postsynaptic inhibition

Journal of Neurophysiology
K Staley

Abstract

1. The relationship of the activation of a voltage-sensitive chloride conductance [GCl(V)] to the chloride transmembrane equilibrium potential (ECl) and the consequent role of this conductance in determining the effect of the gamma-aminobutyric acid-A (GABAA) receptor-mediated transmembrane chloride (Cl-) flux were investigated with the use of whole-cell recordings in the CA1 and dentate gyrus regions of adult rat hippocampal slice preparations. 2. GCl(V) was inwardly rectifying, with significant conductance only at membrane potentials more negative than ECl. For all tested neuronal Cl- concentrations, the activation of GCl(V) could be described by a Boltzman equation with an average half-activation voltage 15 mV negative to ECl, a slope factor of 14 mV, and a maximum conductance of 5 microS. There was no time-dependent inactivation of GCl(V). 3. GCl(V) was modulated by intracellular divalent cations. When magnesium was omitted from the electrode solution, the inward rectification of GCl(V) was unchanged, but the maximum amplitude of GCl(V) increased by a factor of 1.7. GCl(V) was blocked by bath application of 100 microM zinc (Zn2+), but not when 1-6 mM ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid (EGT...Continue Reading

Citations

May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·E M SchwiebertG R Cutting
May 15, 2001·American Journal of Physiology. Cell Physiology·M BaliJ Fritsch
Mar 22, 2006·The Journal of Membrane Biology·G UgarteJ Bacigalupo
Mar 31, 2010·Pflügers Archiv : European journal of physiology·Aristea S Galanopoulou
Aug 3, 2010·Nature Neuroscience·Csaba FöldyIvan Soltesz
Jan 13, 2011·The Journal of Physiology·Rudolf A DeiszRobert Nitsch
May 24, 2017·Molecular Medicine Reports·Hongwei WangXin Wang
Nov 18, 1998·Journal of Neurophysiology·Y B LiuB L Trommer
Mar 2, 1999·The Journal of Physiology·M PuschT J Jentsch
Nov 30, 2005·Cellular and Molecular Life Sciences : CMLS·M SuzukiT Iwamoto
Dec 31, 2015·Tissue Barriers·Younggeon Jin, Anthony T Blikslager
Jul 29, 2005·American Journal of Physiology. Cell Physiology·Alexandre HinzpeterJanine Fritsch
Jul 19, 2011·Neural Plasticity·R WrightC J Akerman
Oct 24, 2014·Frontiers in Physiology·Gabriel StöltingChristoph Fahlke
May 31, 2018·Physiological Reviews·Thomas J Jentsch, Michael Pusch
Mar 28, 2002·Physiological Reviews·Thomas J JentschAnselm A Zdebik
Oct 12, 2007·Physiological Reviews·Yehezkel Ben-AriRustem Khazipov
Jan 1, 2014·International Journal of Molecular Sciences·Miao Miao BiYa Juan Zheng
Dec 27, 2011·The Journal of Physiology·Caren Armstrong, Ivan Soltesz
Dec 6, 2020·Proceedings of the National Academy of Sciences of the United States of America·Anna K KosterJ Du Bois
Jul 3, 2007·The Journal of Experimental Biology·Uwe RoseChristian Walther
Jun 1, 1996·Current Opinion in Neurobiology·T J Jentsch
Aug 7, 1998·Brain Research. Developmental Brain Research·G H ClaytonR L Smith
Sep 5, 1998·Brain Research. Developmental Brain Research·G H ClaytonR L Smith

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