Abstract
The management of mediastinitis involves directing appropriate antibacterial therapy against the potential bacterial pathogens. The increased recovery of anaerobic bacteria from mediastinal infections has led to a greater appreciation of their role in this condition and to re-evaluation of the proper treatment of this condition. Mediastinitis caused by anaerobic bacteria generally emerges following perforation of the oesophagus, extension of retropharyngeal abscess, suppurative parotitis, cervical cellulitis or abscess of dental origin. The bacteria recovered from these infections are often of oral origin and involve mixed aerobic-anaerobic oral flora. The predominant anaerobic isolates include Bacteroides spp., Peptostreptococcus spp., pigmented Prevotella and Porphyromonas spp. and Fusobacterium spp. Treatment includes surgical intervention, antibacterial therapy and supportive measures. Appropriate management of mediastinal infections due to aerobic and anaerobic infections requires the administration of antibacterials that are effective against both the aerobic and anaerobic components of the infection. Selection of antibacterials for the treatment of mediastinitis is determined by bacteriological studies.
References
Apr 1, 1978·Chest·R MoncadaH White
Jan 1, 1991·Scandinavian Journal of Thoracic and Cardiovascular Surgery·T SzerafinA Péterffy
May 1, 1990·The Annals of Thoracic Surgery·M J WheatleyM B Orringer
Jul 1, 1989·British Journal of Plastic Surgery·J J IacobucciG M Deeb
Jan 1, 1971·American Journal of Diseases of Children·R Feldman, D S Gromisch
Mar 1, 1984·Reviews of Infectious Diseases·P M Murray, S M Finegold
Sep 1, 1983·Reviews of Infectious Diseases·D H BorG H Friedland
Mar 1, 1995·Thorax·T M MoleM N Sheppard
Feb 12, 1996·Archives of Internal Medicine·I Brook, E H Frazier
Mar 1, 1996·The Annals of Thoracic Surgery·R M El Oakley, J E Wright
Dec 24, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P MuñozE Bouza
May 22, 1998·The Annals of Thoracic Surgery·P D KiernanB Vaughan
Sep 15, 1999·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·L M SanchoF B Jatene
Dec 16, 2000·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·W Tung-YiuC Hung-An
Jan 13, 2001·The Annals of Thoracic Surgery·J A SaloH J Toivonen
May 30, 2001·International Journal of Pediatric Otorhinolaryngology·J E KerschnerD Lee
Mar 13, 2002·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·Julian E LosanoffBruce W Richman
Citations
May 30, 2013·Antimicrobial Agents and Chemotherapy·Fasahath HusainHannah M Wexler
May 2, 2012·Infection and Immunity·Rajendra P SettemAshu Sharma
Feb 1, 2012·PloS One·Laurent FerrarisJulio Aires
Apr 25, 2012·World Journal of Gastroenterology : WJG·Rita J GustafssonCrister Olsson
Jan 12, 2008·Journal of Occupational and Environmental Medicine·Peter WahlqvistNathan L Kleinman
Jul 4, 2009·Oral Microbiology and Immunology·U K GursoyV-J Uitto
Dec 3, 2014·Anaerobe·Gabriela BancescuMaria Bari
May 4, 2010·International Journal of Systematic and Evolutionary Microbiology·Mareike KraatzLiselott Svensson
Oct 4, 2006·Pediatrics·Toru SasakiNaoki Yahagi