The role of analytical SEM in the determination of causation in malignant mesothelioma

Ultrastructural Pathology
Victor L Roggli

Abstract

The causative relationship between asbestos exposure and mesothelioma is firmly established. Some information in this regard comes from analysis of the fiber content of lung tissue by means of analytical electron microscopy. The author has had the opportunity to study the lung asbestos content of 396 cases of mesothelioma, including 28 peritoneal cases, by means of analytical scanning electron microscopy. The highest fiber levels occurred in patients who also had asbestosis, which was found in 12% of pleural and 43% of peritoneal cases. Elevated tissue asbestos content was identified in 87% of pleural and 75% of peritoneal cases. Peritoneal cases that are asbestos related have on average a higher lung fiber burden than pleural cases. Mesotheliomas in women have elevated tissue asbestos content in about 60% of cases, and many of these had a history of exposure as a household contact of an asbestos worker. The main fiber type identified in our series was amphibole, predominantly amosite. These fibers have been demonstrated to reach the target tissue, the pleura.

References

Oct 1, 1990·The American Review of Respiratory Disease·R F DodsonC Bianchi
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Jan 1, 1996·American Journal of Respiratory and Critical Care Medicine·C BoutinP De Vuyst
May 9, 2001·Industrial Health·Y Suzuki, S R Yuen

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Citations

Feb 28, 2013·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Alessandro CroceCaterina Rinaudo
Nov 18, 2008·Inhalation Toxicology·Ambrogio FassinaMassimo Montisci
Mar 6, 2007·Chemosphere·Furquan Ahmad AnsariQamar Rahman
Mar 28, 2013·American Journal of Industrial Medicine·Georges AdibAndré Dufresne
Oct 31, 2009·International Journal of Cancer. Journal International Du Cancer·Kazuyoshi YanagiharaToshio Seyama
Jul 31, 2013·New Solutions : a Journal of Environmental and Occupational Health Policy : NS·Christopher Meisenkothen

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