The Role of Androgen Receptor Signaling in Ovarian Cancer

Cells
Taichi Mizushima, Hiroshi Miyamoto

Abstract

Emerging evidence has suggested that androgen receptor signaling plays an important role in ovarian cancer outgrowth. Specifically, androgen receptor activation appears to be associated with increased risks of developing ovarian cancer and inducing tumor progression. However, conflicting findings have also been reported. This review summarizes and discusses the available data indicating the involvement of androgens as well as androgen receptor and related signals in ovarian carcinogenesis and cancer growth. Although the underlying molecular mechanisms for androgen receptor functions in ovarian cancer remain far from being fully understood, current observations may offer effective chemopreventive and therapeutic approaches, via modulation of androgen receptor activity, against ovarian cancer. Indeed, several clinical trials have been conducted to determine the efficacy of androgen deprivation therapy in patients with ovarian cancer.

References

Feb 15, 1990·International Journal of Cancer. Journal International Du Cancer·M SawadaK Endo
Mar 1, 1987·Journal of Steroid Biochemistry·R KühnelJ G Stolk
Jan 1, 1985·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·A al-TimimiH Fox
Dec 15, 1983·International Journal of Cancer. Journal International Du Cancer·J CuzickJ L Hayward
Jan 1, 1995·Acta Oncologica·N van der VangeJ B Vermorken
Jul 1, 1995·American Journal of Obstetrics and Gynecology·B Y KarlanL D Lagasse
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S TumoloJ B Vermorken
Sep 1, 1993·European Journal of Obstetrics, Gynecology, and Reproductive Biology·J BlaakaerJ Bock
Oct 1, 1996·Obstetrics and Gynecology·J M SchildkrautC Hughes
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·E GiovannucciP W Kantoff
May 1, 1997·Oncology·M VassilomanolakisA Efremidis
Aug 1, 1997·Gynecologic Oncology·J V IlekisB Scoccia
Sep 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·H MiyamotoC Chang
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·K M LauS M Ho
Feb 24, 2000·Gynecologic Oncology·J J HageE Bloemena
Mar 23, 2000·International Journal of Cancer. Journal International Du Cancer·M H AhonenP Tuohimaa
Oct 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·S YehC Chang
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·R. T. PensonM. V. Seiden
Apr 16, 2002·British Journal of Cancer·R J EdmondsonB R Davies
Feb 21, 2003·International Journal of Cancer. Journal International Du Cancer·Annekatrin LukanovaPaolo Toniolo
Mar 21, 2003·American Journal of Clinical Pathology·George M YousefDionyssios Katsaros
Sep 25, 2004·The Prostate·Hiroshi MiyamotoChawnshang Chang
Oct 27, 2004·Nature Medicine·Kwai Wa ChengGordon B Mills
Apr 2, 2005·Obstetrics and Gynecology·Julia B GreerRoberta B Ness
Dec 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Andrew J LiBeth Y Karlan
Mar 7, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S C KimR E Buller
Mar 8, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Peng-Ming SunJaild Sehouli
Jun 29, 2006·Gynecologic and Obstetric Investigation·Don S DizonCornelius O Granai
Dec 22, 2006·Cancer Letters·Christina M NagleAmanda B Spurdle
Jan 16, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Sabina RinaldiRudolf Kaaks

❮ Previous
Next ❯

Citations

Jul 28, 2020·Frontiers in Immunology·Isabel Ben-BatallaSonja Loges
Oct 16, 2019·The Journal of Steroid Biochemistry and Molecular Biology·Alexandra KollaraTheodore J Brown
Dec 20, 2019·International Immunopharmacology·Anne GompelLaurence Bouillet
May 7, 2021·Endocrine Reviews·Lucie MalbeteauMuriel Le Romancer
Jul 10, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Vittorio E BianchiAntonio Torsello
Jul 25, 2021·International Journal of Molecular Sciences·Wei-Min ChungWen-Lung Ma
Aug 3, 2021·Molecular and Cellular Endocrinology·L VarticovskiG L Hager
Aug 11, 2021·Current Medicinal Chemistry·Erva Ozkan, Filiz Bakar-Ates

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
xenograft
PCR
nuclear translocation

Clinical Trials Mentioned

NCT01974765

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved