The role of androgens in metabolism, obesity, and diabetes in males and females

Obesity
Guadalupe NavarroFranck Mauvais-Jarvis

Abstract

In men, androgen deprivation contributes to the development of metabolic syndrome and type 2 diabetes (T2D). In women, androgen excess predisposes to insulin resistance and T2D. There is a bidirectional modulation of glucose homeostasis by androgens in males and females that is analyzed in this review. We reviewed the literature in both rodents and humans on the role of androgens and the androgen receptor (AR) in the control of glucose and energy metabolism in health, obesity, and T2D. Sex-specific activation of AR in the hypothalamus, skeletal muscle, liver, adipose tissue, and pancreatic islet β-cells accounts for maintenance or disruption in energy metabolism and glucose homeostasis. We argue that AR is a target to prevent androgen-related metabolic disorders.

References

Sep 1, 1992·Annals of Epidemiology·K T Khaw, E Barrett-Connor
Dec 1, 1992·Acta Physiologica Scandinavica·A Holmäng, P Björntorp
May 1, 1988·Diabetic Medicine : a Journal of the British Diabetic Association·M EmaraF F Fenech
Jul 1, 1994·The Journal of Clinical Endocrinology and Metabolism·K H PoldermanR J Heine
May 1, 1994·Diabetes Care·B AnderssonP Björntorp
Feb 1, 1993·Endocrine Reviews·C BouchardP Mauriège
May 1, 1993·The Journal of Clinical Endocrinology and Metabolism·N M O'MearaK S Polonsky
Jun 20, 2001·Life Sciences·S MorimotoV Díaz-Sánchez
Dec 14, 2002·Biochemical and Biophysical Research Communications·Takashi SatoShigeaki Kato
Mar 9, 2004·Yonsei Medical Journal·Kyung Soon Song, Hyun Kyung Kim
Mar 31, 2004·Clinical Endocrinology·Fabio LanfrancoEberhard Nieschlag
Oct 28, 2004·The Journal of Clinical Endocrinology and Metabolism·Mark O GoodarziStanley G Korenman
Feb 9, 2006·The Journal of Clinical Endocrinology and Metabolism·Frank GonzálezJohn P Kirwan
Mar 16, 2006·JAMA : the Journal of the American Medical Association·Eric L DingSimin Liu
Aug 24, 2006·The Journal of Clinical Endocrinology and Metabolism·Michael ZitzmannEberhard Nieschlag
Sep 14, 2006·American Journal of Physiology. Endocrinology and Metabolism·Marcello MaggioLuigi Ferrucci
Sep 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nancy L KeatingMatthew R Smith
May 2, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hung-Yun LinChawnshang Chang
Feb 20, 2009·International Journal of Andrology·Henry VölzkeHenri Wallaschofski
Apr 7, 2009·Metabolic Syndrome and Related Disorders·Gabrielle Page-WilsonKathryn M Rexrode
Oct 28, 2009·Nature Reviews. Endocrinology·Michael Zitzmann

❮ Previous
Next ❯

Citations

Feb 15, 2016·Reproductive Biomedicine Online·Livio CasariniGiulia Brigante
Feb 11, 2016·Journal of Diabetes and Its Complications·Franck Mauvais-Jarvis
Jan 23, 2016·Diabetologia·Mehboob A HussainWoo-Jin Song
Jan 18, 2016·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Leandro Fernández-PérezJuan Carlos Díaz-Chico
Jul 15, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yuuri TakeshitaKohzo Nagata
Oct 22, 2015·Diabetes Care·Fabrice BonnetGuy Fagherazzi
Apr 12, 2016·International Journal of Dermatology·Mahira H El SayedNohha H Khater
Sep 5, 2015·Biology of Sex Differences·Franck Mauvais-Jarvis
Jun 30, 2016·Diabetes & Metabolic Syndrome·Shalini Verma, M Ejaz Hussain
Jun 8, 2017·Cell Metabolism·Franck Mauvais-JarvisKaren Reue
Jun 29, 2017·Journal of Alzheimer's Disease : JAD·Prita R AsihRalph N Martins
Jan 4, 2018·International Journal of Environmental Research and Public Health·Sugunadevi SakkiahHuixiao Hong
May 2, 2018·Health Psychology Review·Darby SaxbeHannah Lyden Khoddam
Nov 15, 2017·Hypertension·Jessica L Faulkner, Eric J Belin de Chantemèle
Jan 3, 2019·The Journal of Endocrinology·Weiwei XuFranck Mauvais-Jarvis
May 10, 2016·Endocrine Reviews·Alexandra Kautzky-WillerGiovanni Pacini
May 11, 2019·Endocrine Reviews·Sandra Handgraaf, Jacques Philippe
Aug 16, 2017·Scientific Reports·Romina FornesElisabet Stener-Victorin
Jan 8, 2020·American Journal of Physiology. Endocrinology and Metabolism·Binbin HuangJian V Zhang
Jul 3, 2019·Biology of Sex Differences·Jessica L Faulkner, Eric J Belin de Chantemèle
May 20, 2020·Journal of Women's Health·T Rajendra KumarJudith G Regensteiner
Jun 12, 2020·Internal Medicine·Nobuo KajitaniShinichiro Ando
Jul 1, 2020·Diabetes/metabolism Research and Reviews·Wenning FuZuxun Lu
Jan 25, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·A E Newell-Fugate
Jun 6, 2018·Frontiers in Endocrinology·Luz AndreoneMarcelo J Perone
Feb 6, 2019·Experimental Biology and Medicine·Suresh Mishra, Bl Grégoire Nyomba
Nov 2, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Mehdi BasakiSaeedeh Saeb
Apr 30, 2017·Current Hypertension Reports·Costanzo MorettiEnrico Carmina
Aug 18, 2018·Scientific Reports·Suwattanee KooptiwutPa-Thai Yenchitsomanus
Dec 22, 2019·Reviews in Endocrine & Metabolic Disorders·Giovanni CoronaFrancesco Lombardo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asprosin

Asprosin is a fasting-induced hormone produced in the white adipose tissue to stimulate the hepatic release of glucose into the bloodstream. Discover the latest research on this protein hormone here.

Related Papers

Current Hypertension Reports
Mohadetheh MoulanaJane F Reckelhoff
Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research
Preetha BalakrishnanGloria Lena Vega
© 2022 Meta ULC. All rights reserved