The Role of Anesthetic Management in Surgical Site Infections After Pediatric Intestinal Surgery.

The Journal of Surgical Research
Miho Shibamura-FujiogiKoichi Yuki

Abstract

Although surgical site infections (SSIs) remain a significant health care issue, a limited number of studies have analyzed risk factors for SSIs in children, particularly the role of intraoperative anesthetic management. Pediatric patients are less likely to have major adult risk factors for SSIs such as smoking and diabetes. Thus children may be more suitable as a cohort for examining the role of intraoperative anesthetics in SSIs. We examined an association between SSI incidence and anesthetic management in children who underwent elective intestinal surgery in a single institution. We performed a retrospective study of 621 patients who underwent elective intestinal surgery under general anesthesia between January 2017 and September 2019, with primary outcome as the incidence of SSIs. We compared patients who were dichotomized in accordance with the median of the sevoflurane dose. We used propensity score (PS) pairwise matching of these patients to avoid selection biases. PS matching yielded 204 pairs of patients. We found that higher doses of sevoflurane were associated with a higher incidence of SSIs (9.8% versus 3.9%, P = 0.019). We adjusted for intraoperative factors that were not included in the PS adjustment factors, and...Continue Reading

References

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Jan 9, 2015·Cardiovascular & Hematological Disorders Drug Targets·Koichi Yuki, Naoka Murakami
Jun 17, 2016·Anesthesia and Analgesia·Koichi Yuki, Roderic G Eckenhoff
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Nov 7, 2016·The Lancet Infectious Diseases·Benedetta AllegranziUNKNOWN WHO Guidelines Development Group
Dec 13, 2016·Toxicology Letters·Kazumasa TazawaKoichi Yuki
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Dec 7, 2018·The Journal of Surgical Research·Sophia KoutsogiannakiKoichi Yuki
Nov 2, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Toshiaki OkunoKoichi Yuki
Mar 10, 2020·Anesthesia and Analgesia·Yusuke MitsuiKoichi Yuki

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Citations

Mar 26, 2021·BioMed Research International·Koichi Yuki, Miho Shibamura-Fujiogi
May 3, 2021·International Immunopharmacology·Koichi Yuki

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