The role of angiogenesis in the development of proliferative diabetic retinopathy: impact of intravitreal anti-VEGF treatment.

Experimental Diabetes Research
Gemma TremoladaGianpaolo Zerbini

Abstract

Although cellular and molecular bases of proliferative diabetic retinopathy are only partially understood, it is evident that this complication of diabetes is characterized by the formation of new vessels inside the retina showing abnormal architecture and permeability. This process, if not controlled by selective laser photocoagulation, leads to irreversible retinal damages and loss of vision. Angiogenesis, that is, the condition characterized by the growth of new blood vessels originated from preexisting ones, was shown to have a major role in the pathogenesis of proliferative retinopathy and, as a consequence, intravitreal antiangiogenic injection was suggested as a feasible treatment for this disease. Here, we describe the different antiangiogenic approaches used to treat this disease along with the respective advantages and limitations when compared to laser treatment. Altogether, even though further and longer studies are still needed to clarify the best possible therapeutic protocol, the antiangiogenic treatment will reasonably have a future role in the therapy and prevention of proliferative diabetic retinopathy.

References

May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·G S RobinsonL E Smith
Aug 1, 1996·Archives of Ophthalmology·G A LuttyJ Plouét
Sep 15, 1999·Proceedings of the National Academy of Sciences of the United States of America·K MiyamotoA P Adamis
Feb 28, 2002·American Journal of Ophthalmology·Michael J TolentinoGerard A Lutty
Mar 26, 2003·Journal of Cellular Physiology·Yoshitsugu SaishinPeter A Campochiaro
Mar 29, 2003·Diabetes Care·Peter HovindHans-Henrik Parving
Apr 26, 2003·Investigative Ophthalmology & Visual Science·Susumu IshidaAnthony P Adamis
Aug 2, 2003·The New England Journal of Medicine·James C YangSteven A Rosenberg
Dec 25, 2003·Diabetes Care·Donald S FongUNKNOWN American Diabetes Association
Jun 4, 2004·The New England Journal of Medicine·Herbert HurwitzFairooz Kabbinavar
Dec 31, 2004·The New England Journal of Medicine·Evangelos S GragoudasUNKNOWN VEGF Inhibition Study in Ocular Neovascularization Clinical Trial Group
Dec 14, 2005·Ophthalmology·Anthony P AdamisUNKNOWN Macugen Diabetic Retinopathy Study Group
May 2, 2006·Ophthalmology·UNKNOWN VEGF Inhibition Study in Ocular Neovascularization (V.I.S.I.O.N.) Clinical Trial GroupB Katz
Jun 14, 2006·Archives of Ophthalmology·Magdalena G KrzystolikJohn I Loewenstein
Aug 29, 2006·Diabetes Care·K M Venkat NarayanTheodore J Thompson
Oct 6, 2006·The New England Journal of Medicine·Philip J RosenfeldUNKNOWN MARINA Study Group
Aug 4, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Lihteh WuUNKNOWN Pan American Collaborative Retina Group (PACORES)
Nov 13, 2007·Acta Ophthalmologica·Angelo M MinnellaEmilio Balestrazzi
Feb 21, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Stanislao RizzoGeorge Williams
Mar 6, 2008·European Journal of Ophthalmology·K V ChalamS Agarwal
Jul 17, 2008·PloS One·Esther J KuiperReinier O Schlingemann
Jul 18, 2008·Acta Ophthalmologica·Jost B JonasFlorian Rensch
Aug 13, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Siamak MoradianMohsen Azarmina
Nov 27, 2008·British Journal of Clinical Pharmacology·Ciro CostagliolaMario R Romano
Jan 8, 2009·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Michael Thew

❮ Previous
Next ❯

Citations

Jan 12, 2013·Reviews in Endocrine & Metabolic Disorders·Cathryn M Kolka, Richard N Bergman
Nov 27, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Stefano FogliRomano Danesi
Oct 25, 2016·Journal of Traditional and Complementary Medicine·Mohammad Hossein DehghanSalume Salehi
Dec 18, 2015·Prostaglandins & Other Lipid Mediators·Tapan BehlAnita Kotwani
Mar 10, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yuan TaoQian Li
Feb 24, 2015·PPAR Research·Elizabeth P Moran, Jian-Xing Ma
Mar 12, 2013·Renal Failure·Theodoros EleftheriadisIoannis Stefanidis
Jul 24, 2014·Journal of Receptor and Signal Transduction Research·Akanksha GuptaSonika Bhatnagar
Feb 3, 2015·Biochimica Et Biophysica Acta·Zengyang YuZhengtao Wang
May 20, 2014·Biochimica Et Biophysica Acta·Rajesh N Gacche, Rohan J Meshram
Jun 18, 2016·Stem Cells International·Cai-Guo YuDong Zhao
Jul 17, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Jinlu LiuXiaohan Qu
May 27, 2020·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Işıl Kutlutürk KaragözSahar Dinparvar
Sep 15, 2018·Current Protein & Peptide Science·Ankita SolankiKedar S Prabhavalkar
Jul 22, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Eman A ToraihManal S Fawzy
Aug 17, 2020·The Journal of Clinical Endocrinology and Metabolism·Ying YangKe Yang
Feb 10, 2021·Molecular Biology Reports·Tuhin MukherjeeSimona Bungau
May 1, 2021·Journal of Personalized Medicine·Kyoung Min KimJung Kee Min
May 13, 2021·Experimental Eye Research·Nidhi KumariSenthil Kumar Ganesan

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.