The role of angiogenic, anti-angiogenic and vasoactive factors in pre-eclamptic African women: early- versus late-onset pre-eclampsia.

Cardiovascular Journal of Africa
Lucinda GovenderJack Moodley

Abstract

The pathogenesis and aetiology of pre-eclampsia (PE) is still unclear. We investigated the role of angiogenic, antiangiogenic and vasoactive factors in black South African women with early- and late-onset PE. Serum soluble fms-like tyrosine kinase 1 (sFlt-1), soluble vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) levels were determined using the ELISA technique, and placental mRNA expression levels of sFlt-1, VEGF, PlGF and AT1 receptors were determined using real-time PCR. Serum sFlt-1 levels were significantly elevated and PlGF significantly reduced in early-onset PE compared to the normotensive group. Placental VEGF mRNA expression levels were significantly reduced in the late-onset preeclamptic group compared with the normotensives. The placental mRNA expression of AT1 receptor in the late-onset pre-eclamptic group was relatively raised compared to the normotensives, suggesting hypersensitivity to pressor agents. We believe that the excess of serum sFlt-1 and reduced VEGF and PlGF levels favour an anti-angiogenic state and endothelial dysfunction leading to PE, and that the aetiology and pathogenesis of early- and late-onset PE differ.

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Citations

Sep 3, 2014·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Ewa Wender-OzegowskaJacek Brązert
Apr 14, 2016·American Journal of Obstetrics and Gynecology·Juan YangMartin Kharrazi
Sep 10, 2020·Frontiers in Cellular and Infection Microbiology·Kehinde S OlaniyiIrene Mackraj
Dec 21, 2016·Molecular and Cellular Biochemistry·Sooraj BaijnathJagidesa Moodley
Jun 24, 2017·Clinical and Experimental Pharmacology & Physiology·Weiyan GongXiaojing Zhang
Oct 24, 2020·American Journal of Obstetrics and Gynecology·Sarosh RanaS Ananth Karumanchi
Jul 3, 2021·Journal of Clinical Medicine·Elżbieta Poniedziałek-CzajkowskaBożena Leszczyńska-Gorzelak
Jul 30, 2021·BMC Pregnancy and Childbirth·Megan E SmithmyerJoan T Price

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Methods Mentioned

BETA
ELISA
PCR
biopsies

Software Mentioned

SPSS

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