The role of angiotensin-converting enzyme and apolipoprotein-E gene polymorphisms on lipid compositions in newborn infants with intrauterine growth restriction

Early Human Development
Mete AkisuNilgun Kultursay

Abstract

Recent findings suggest that hypertension, dyslipidemia, diabetes mellitus, coronary heart disease are more common in adults who born with intrauterine growth restriction (IUGR). Several studies have shown that polymorphisms in angiotensin-converting enzyme (ACE) and apolipoprotein-E (Apo-E) are effective in developing the insulin resistance and also in increasing the risk of coronary heart disease. In present study, the frequencies of ACE, Apo-E gene polymorphisms, apolipoprotein-B (Apo-B) mutation and lipid compositions were determined in full-term newborn infants with IUGR. Forty-four newborn infants who had completed 36 weeks of gestational age, 24 healthy infants and 20 with IUGR, were taken into the scope of the study. While total cholesterol (TC) and Apo-B concentrations in infants with IUGR was found to be significantly higher than that of the control group (p<0.05), triglyceride (TG), low-density lipoproteins (LDL), high-density lipoproteins (HDL) and Apo-A1 levels were similar (p>0.05). An insertion/deletion (I/D) polymorphism with a significantly increased frequency was observed in the IUGR group (65%) as compared with the control group (33%) (p<0.05). When the distribution of the Apo-E gene polymorphism (E2, E3 and ...Continue Reading

References

Mar 31, 1970·Biochimica Et Biophysica Acta·W V BrownD S Fredrickson
Aug 1, 1995·Clinical and Experimental Pharmacology & Physiology·E R Lumbers
Jun 1, 1994·Diabetologia·D I PhillipsC Osmond
Jun 1, 1994·Pediatric Research·C R ParkerT K Barefoot
Feb 1, 1994·Diabetologia·D I PhillipsC Osmond
Jan 2, 1993·BMJ : British Medical Journal·C M LawC H Fall
May 14, 1998·European Journal of Pediatrics·H MerzoukJ Prost
Jul 17, 1998·Frontiers in Neuroendocrinology·A M Poisner
Jan 14, 2000·The Journal of Clinical Endocrinology and Metabolism·N RadunovicC J Lockwood
Apr 19, 2000·The Journal of Clinical Endocrinology and Metabolism·D JaquetC Levy-Marchal
May 8, 2000·Indian Journal of Pediatrics·M AkisüN Kültürsay
Aug 15, 2000·Placenta·A H NielsenK Poulsen
Feb 24, 2001·Pediatrics International : Official Journal of the Japan Pediatric Society·M AkisuN Kültürsay
Nov 6, 2001·Molecular and Cellular Endocrinology·P S LeungT K Lau
Dec 12, 2001·European Journal of Clinical Investigation·O S DescampsF R Heller

❮ Previous
Next ❯

Citations

Aug 23, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·David Harding
Apr 14, 2006·Hormone Research·D B DungerK K Ong
Dec 14, 2011·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Eiki NakamuraTokitsugi Hayashi
Aug 6, 2013·European Journal of Pediatrics·Caroline PonzioMaria C P Franco
Jul 14, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Digna R Velez EdwardsScott M Williams
Apr 1, 2012·Pregnancy Hypertension·Saeideh ZiaeiAnoshirvan Kazemnejad
Sep 11, 2007·Seminars in Perinatology·Claire Infante-Rivard
Oct 13, 2006·Annals of Human Genetics·P C HindmarshS E Humphries
Apr 20, 2006·Diabetes Research and Clinical Practice·Puneet Pal SinghSarabjit Mastana
Apr 24, 2010·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Andrea LouiMichael Obladen
Oct 21, 2006·FEMS Immunology and Medical Microbiology·Hervé C GérardAlan P Hudson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.