PMID: 11330825May 2, 2001Paper

The role of angiotensin II, endothelin-1 and transforming growth factor-beta as autocrine/paracrine mediators of stretch-induced cardiomyocyte hypertrophy

Molecular and Cellular Biochemistry
A E van WamelA van der Laarse

Abstract

Cardiac hypertrophy is a compensatory response of myocardial tissue upon increased mechanical load. Of the mechanical factors, stretch is rapidly followed by hypertrophic responses. We tried to elucidate the role of angiotensin II (AII), endothelin-1 (ET-1) and transforming growth factor-beta (TGF-beta) as autocrine/paracrine mediators of stretch-induced cardiomyocyte hypertrophy. We collected conditioned medium (CM) from stretched cardiomyocytes and from other stretched cardiac cells, such as cardiac fibroblasts, endothelial cells and vascular smooth muscle cells (VSMCs). These CMs were administered to stationary cardiomyocytes with or without an AII type 1 (AT1) receptor antagonist (losartan), an ET-1 type A (ET(A)) receptor antagonist (BQ610), or anti-TGF-beta antibodies. By measuring the mRNA levels of the proto-oncogene c-fos and the hypertrophy marker gene atrial natriuretic peptide (ANP), the molecular phenotype of the CM-treated stationary cardiomyocytes was characterized. Our results showed that c-fos and ANP expression in stationary cardiomyocytes was increased by All release from cardiomyocytes that had been stretched for 60 min. Stretched cardiomyocytes, cardiac fibroblasts and endothelial cells released ET-1 which ...Continue Reading

Citations

Jul 20, 2005·Experimental Lung Research·Marc CloutierJean-Martin Laberge
Sep 27, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·Hung-Yu YangTzu-Hurng Cheng
Dec 13, 2005·The FEBS Journal·Angelika HorstmeyerThomas Krieg
Jan 13, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Tepmanas Bupha-IntrPaul M L Janssen
May 26, 2009·Heart and Vessels·Caroline Fernandes-SantosCarlos Alberto Mandarim-de-Lacerda
Aug 12, 2009·Hepatology International·Florence Wong
Jul 9, 2010·International Journal of Endocrinology·Gabriela Placoná DinizMaria Luiza Morais Barreto-Chaves
Sep 3, 2010·The Journal of Clinical Investigation·Polakit TeekakirikulJonathan G Seidman
May 28, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Lorena A VargasBernardo V Álvarez
Apr 11, 2015·Circulation Research·Jay D HumphreyDianna M Milewicz
Apr 8, 2017·The Journal of Pharmacology and Experimental Therapeutics·Logan SladeThomas Pulinilkunnil
Sep 10, 2017·Journal of Cellular Physiology·Sarfaraz AhmadHao Wang
Nov 14, 2017·PLoS Computational Biology·Philip M TanJeffrey J Saucerman
Jan 27, 2019·Nature Reviews. Cardiology·Jeffrey J SaucermanJeffrey H Omens
Feb 12, 2019·Pflügers Archiv : European journal of physiology·Theresia Kraft, Judith Montag
Dec 10, 2019·Canadian Journal of Physiology and Pharmacology·Christopher J OldfieldNaranjan S Dhalla
Nov 16, 2002·Circulation Research·Mark A SussmanThomas K Borg
Jan 24, 2003·American Journal of Respiratory Cell and Molecular Biology·Daniel J TschumperlinJeffrey M Drazen
Mar 7, 2007·Circulation·Horacio E Cingolani, Irene L Ennis
Aug 22, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Oksana ShynlovaStephen J Lye
Oct 24, 2007·Basic Research in Cardiology·William J TuxworthDhandapani Kuppuswamy
Dec 25, 2008·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Julie De Backer
Mar 12, 2010·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Jia HaoChan-Hyung Kim
Mar 19, 2016·Circulation Research·Joshua G TraversBurns C Blaxall
Jan 31, 2020·Cardiovascular Research·Paolo G CamiciSophie Van Linthout
Jun 18, 2004·Annals of the New York Academy of Sciences·Jan LammerdingRichard T Lee
Mar 1, 2014·Circulation Research·Hans J de HaasJagat Narula
Mar 1, 2019·The Journal of Physiology·Andrea CollivaSerena Zacchigna
Sep 6, 2019·JCI Insight·Yina MaLawrence H Young
May 6, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ying-Min ZhangLei Wei
Jul 19, 2003·American Journal of Respiratory and Critical Care Medicine·Lina H K Lim, Elizabeth M Wagner
Dec 5, 2009·Circulation Research·Colby A SoudersTroy A Baudino
Feb 28, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Graham R LeeBarbara J McDermott
Apr 3, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Betty S HuWayne R Giles
Aug 24, 2012·Journal of Cardiovascular Translational Research·Kalyani D PanseEnrique Lara-Pezzi

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