The role of angiotensin II in cognition and behaviour

European Journal of Pharmacology
Paul R Gard


Polymorphisms of the renin-angiotensin system are associated with cardiovascular disorders, possibly as a consequence of increased brain angiotensin II activity. Within the brain, angiotensin controls blood pressure, fluid balance and hormone secretion; it also influences behaviour: reduction of central angiotensin function has both antidepressant-like and axiolytic-like actions. Evidence concerning the role of the renin-angiotensin system in learning and memory is contradictory, although more studies support the proposal that angiotensin reduces cognitive function. Studies of renin-angiotensin system genotype and psychological status have suggested an association between the angiotensin-converting enzyme deletion allele and age related cognitive decline, but a greater prevalence of the insertion allele in Alzheimer's disease. The deletion allele has also been associated with depressive illness, as has the M allele of the angiotensinogen gene although other studies have failed to replicate these findings. The role of the brain renin-angiotensin system in human psychopathology remains to be fully explored.


Feb 18, 1977·Brain Research·N E SirettJ I Hubbard
Jun 1, 1978·Canadian Journal of Physiology and Pharmacology·M J Katovich, M J Fregly
Nov 1, 1992·Pharmacology, Biochemistry, and Behavior·A TsudaH Emoto
Dec 20, 1991·Brain Research·J B DennyD L Armstrong
May 1, 1990·Pharmacology, Biochemistry, and Behavior·B CostallD M Tomkins
Mar 15, 1989·Biological Psychiatry·W J Giardina, D M Ebert
Mar 1, 1989·Pharmacology, Biochemistry, and Behavior·B CostallD M Tomkins
Oct 1, 1988·American Journal of Obstetrics and Gynecology·T NakamuraH Okamura
Mar 15, 1988·Biological Psychiatry·L Germain, G Chouinard
Jun 26, 1986·The New England Journal of Medicine·S H CroogG H Williams
Dec 1, 1986·Biological Psychiatry·R F Deicken
Jan 1, 1987·Annual Review of Physiology·M I Phillips
May 1, 1974·Pharmacology, Biochemistry, and Behavior·M Tang, J L Falk
Dec 1, 1971·Physiology & Behavior·K A Houpt, A N Epstein
Nov 1, 1971·European Journal of Pharmacology·Y GutmanP Livneh
Jan 1, 1984·Rinsho byori. The Japanese journal of clinical pathology·K Kondo, H Sokabe
Jan 1, 1984·The American Journal of Psychiatry·G S Zubenko, R A Nixon
Nov 3, 1994·European Journal of Pharmacology·P R GardA J Meakin
Apr 1, 1994·Clinical and Experimental Pharmacology & Physiology·D Z WangR Di Nicolantonio
Jun 1, 1993·Pharmacology, Biochemistry, and Behavior·M J WaynerJ B Denny
Jan 1, 1993·Alzheimer Disease and Associated Disorders·A SudilovskyS Repetti
Jan 19, 1993·European Journal of Pharmacology·J M BarnesN M Barnes
Nov 10, 1995·Regulatory Peptides·J W Wright, J W Harding
Aug 5, 1996·Brain Research·W WilsonH Fink
Jan 1, 1997·Progress in Neuro-psychopharmacology & Biological Psychiatry·C Hölscher
Jun 1, 1997·American Journal of Human Genetics·X JeunemaitreJ M Lalouel
Nov 25, 1997·Brain Research. Brain Research Reviews·J W Wright, J W Harding
Jan 13, 1998·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·W Karwowska-PoleckaJ J Braszko

❮ Previous
Next ❯


Mar 13, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Björn MaulThomas Walther
Apr 13, 2011·Psychopharmacology·Rasha MechaeilJennifer Rusted
Apr 27, 2012·Pflügers Archiv : European journal of physiology·John W Wright, Joseph W Harding
Nov 9, 2007·Heart Failure Reviews·Shigehiko MizutaniJohn W Wright
Jun 15, 2011·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Jinzhi OuyangXu Zhang
May 5, 2005·Brain Research·Jörg-Peter VoigtHeidrun Fink
Dec 13, 2003·Neurobiology of Learning and Memory·F A M de SouzaA M de Oliveira
Mar 9, 2004·Neuropeptides·Alasdair MacKenzie, John P Quinn
Jun 5, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Marialaura AmadioAlessia Pascale
Jun 14, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Brigitta BondyRainer Rupprecht
Aug 21, 2003·Progress in Neurobiology·Mark J Millan
Mar 3, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ihab HajjarPaul Eleazer
Nov 1, 2012·Neuro-oncology·Dana Greene-Schloesser, Mike E Robbins
Jan 6, 2009·BMC Neuroscience·Paul R Gard
Jun 17, 2004·Journal of Basic and Clinical Physiology and Pharmacology·Jan J BraszkoPaul R Gard
Apr 16, 2004·Drugs & Aging·Roberto Fogari, Annalisa Zoppi
Mar 24, 2006·Cell and Tissue Research·O von Bohlen und Halbach, D Albrecht
Dec 6, 2012·Parkinson's Disease·John W Wright, Joseph W Harding
Feb 9, 2012·International Journal of Hypertension·James A McCubbinJune J Pilcher
Jun 19, 2012·Psychiatry Research·Warren D TaylorAllison Ashley-Koch
Nov 24, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Giovambattista De SarroEmilio Russo
Jul 23, 2011·Progress in Neurobiology·John W Wright, Joseph W Harding
Sep 29, 2009·Experimental Neurology·John W Wright, Joseph W Harding
Jun 27, 2009·Clinics in Geriatric Medicine·Thomas Olabode Obisesan
Jul 9, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lise Grimmeshave Bie-OlsenBirger Thorsteinsson
Dec 17, 2008·International Journal of Radiation Oncology, Biology, Physics·Mike E RobbinsWeiling Zhao
Aug 19, 2008·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Christiane A MelzigJulian F Thayer
Sep 6, 2008·Neuroscience and Biobehavioral Reviews·Julian F Thayer, Richard D Lane
Jun 2, 2007·Journal of Psychosomatic Research·Takashi HayashiKazuo Murakami
Sep 4, 2012·Experimental Physiology·Paul J Marvar, David G Harrison
Mar 16, 2011·The Journal of Pharmacy and Pharmacology·Paul R GardDenis Ryan
Sep 16, 2010·The International Journal of Pharmacy Practice·Paul R Gard
Jan 11, 2013·International Journal of Hypertension·Masaki MogiMasatsugu Horiuchi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Genetics

Alzheimer's disease is a neurodegenerative disease. Discover genetic and epigenetic aspects of Alzheimer’s disease, including genetic markers and genomic structural variations with this feed.

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.