The role of angiotensin II type 1 receptor antagonists in elderly patients with hypertension

Drugs & Aging
G Neil ThomasBrian Tomlinson

Abstract

Hypertension is a major risk factor for stroke and coronary events in elderly people and clinical trials have shown that treatment of hypertension with various drugs can result in a substantial reduction in cerebrovascular and cardiovascular events. The angiotensin II type 1 (AT1) receptor antagonists are the newest class of antihypertensive agents to be used widely in clinical practice. AT1 receptor antagonists can generally be given once-daily. They are also extremely well tolerated with minimal first-dose hypotension and an incidence of adverse effects similar to that seen with placebo. Adverse event rates are significantly lower than with other classes of antihypertensive drugs including ACE inhibitors. These factors result in improved compliance and increased rates of continuance on therapy. AT1 receptor antagonists show similar efficacy in lowering blood pressure to other classes of antihypertensive agents and their antihypertensive effect is potentiated when they are given concomitantly with low-dose thiazide diuretics. AT1 receptor antagonists are eliminated predominantly by the hepatic route but most are not subject to extensive metabolism and interactions with other drugs are uncommon. This is an advantage in the elde...Continue Reading

References

Nov 1, 1975·Kidney International·P WeidmannJ de Lima
Aug 1, 1981·Journal of the American Geriatrics Society·M NakamaruK Murakami
Nov 1, 1994·Drugs & Aging·J BelminJ B Michel
Nov 1, 1995·Drugs & Aging·Z H Israili, W D Hall
Jan 1, 1997·Clinical Pharmacokinetics·C CsajkaJ Biollaz
Jan 1, 1997·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·F WaldmeierM De Gasparo
Feb 1, 1997·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·B TomlinsonJ A Critchley
Feb 12, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·D DuclouxJ M Chalopin
May 20, 1998·Drugs·K J McClellan, J A Balfour
May 20, 1998·Journal of Clinical Pharmacology·M R MarinoK C Lasseter
May 30, 1998·Biopharmaceutics & Drug Disposition·A SioufiP Lloyd
Oct 9, 1998·British Journal of Clinical Pharmacology·D M TeneroD K Jorkasky
Dec 23, 1998·British Journal of Clinical Pharmacology·N N VachharajaniD S Greene
Jan 8, 1999·Drugs·K J McClellan, A Markham
May 5, 1999·Circulation·W Schaper, I Buschmann

❮ Previous
Next ❯

Citations

Mar 1, 2007·Vascular Health and Risk Management·Roland Asmar, Sophie Nisse-Durgeat
Sep 29, 2011·Expert Opinion on Drug Metabolism & Toxicology·Hae Won LeeYoung-Ran Yoon
Apr 25, 2008·Expert Opinion on Drug Metabolism & Toxicology·Barbara H Rosario, Timothy James Hendra
May 18, 2012·The Journal of Headache and Pain·Paola SarchielliGiorgio Zanchin
Jul 22, 2008·The American Journal of Medicine·Laura Pedelty, Philip B Gorelick
May 7, 2008·Archives of Gerontology and Geriatrics·Roberto FogariGiuseppe Derosa
Feb 1, 2008·The Journal of Clinical Hypertension·Joel M Neutel, Lawrence I Gilderman
Oct 18, 2016·Drugs -- Real World Outcomes·Tariq M AlhawassiLisa G Pont
May 9, 2007·Hypertension·Robert M Carey
Sep 18, 2012·Metallomics : Integrated Biometal Science·Phanichand KodaliOpeolu Adeoye
Jul 24, 2020·International Journal of Molecular Sciences·Amanda J MillerAmy C Arnold

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.