The role of anti-CGRP antibodies in the pathophysiology of primary headaches

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Piero BarbantiPatrizia Ferroni

Abstract

Calcitonin gene-related peptide (CGRP), a potent vasodilator and pain-signaling neuropeptide, is a validated therapeutic target for migraine and cluster headache. Four anti-CGRP monoclonal antibodies (mAbs) have been developed, representing the first specific, mechanism-based, migraine prophylactic treatment. CGRP mAbs demonstrated good efficacy coupled to excellent tolerability and safety in 5 phase II clinical trials. Notably, CGRP mAbs induced complete migraine remission in a patients' subset. To date, more than 20 phase III trials using CGRP mAbs for of episodic and chronic migraine and cluster headache prevention are ongoing. Future investigations will shed light on migraine endophenotypes predictive of good CGRP mAbs responsiveness and provide answers on their long-term cardiovascular safety.

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Citations

Feb 23, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Piero BarbantiN Vanacore
Apr 15, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Reza FekrazadBahram Movahedi
Jan 18, 2018·The Journal of Headache and Pain·Michael J M FischerKarl Messlinger
Mar 30, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Piero BarbantiGabriella Egeo
Apr 16, 2019·Headache·Smriti IyengarSheena K Aurora
Jan 13, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ilaria Di Donato, Antonio Federico
Jan 16, 2020·Brain Sciences·Andrea Carmine BelinLars Edvinsson
Sep 1, 2019·The Journal of Headache and Pain·Elio Clemente AgostoniUNKNOWN Italian chronic migraine group
Jun 23, 2018·Current Medicinal Chemistry·Patrizia FerroniFiorella Guadagni
Aug 19, 2018·Journal of Neurology·Srdjan Ljubisavljevic, Jasna Zidverc Trajkovic
Oct 16, 2020·Molecular Pain·Jia-Yi LiaoZeng-Xu Liu

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