The role of anti-citrullinated protein antibodies (ACPA) in the pathogenesis of rheumatoid arthritis

Central-European Journal of Immunology
Weronika KurowskaWłodzimierz Maśliński

Abstract

The most specific autoimmunity known for rheumatoid arthritis (RA) is reflected by generation of anti-citrullinated protein antibodies (ACPA). Presence of ACPA in established RA is associated with disease severity, while generation of ACPA at early developmental phases of RA can have a strong predictive value for progressing to the full-blown disease. Hence, development of ACPA may be of crucial importance to the pathogenesis of RA. Therefore, a lot of effort has been put recently to investigate the feature of ACPA at early developmental stages of RA (before disease onset) and functional activities of these autoantibodies. Results of these studies enlarged the knowledge about the nature of ACPA, which is essential for planning the therapeutic or preventive strategies interfering with their development and pathogenic functions. In this review we describe recent evidence for a role of ACPA in the etiopathogenesis of RA and indicate key unresolved issues regarding ACPA biology that need to be clarified in the future.

Citations

Feb 23, 2020·RMD Open·Axel FinckhUNKNOWN Recherche clinique en rhumatismes inflammatoires
Oct 3, 2020·Inflammopharmacology·Alireza HejratiParisa Zafari
Sep 14, 2019·Circulation Research·Nicoletta SorvilloDenisa D Wagner
May 28, 2020·Journal of Clinical Medicine·Weronika KurowskaWlodzimierz Maslinski
Dec 3, 2020·International Journal of Molecular Sciences·Chary Lopez-PedreraCarlos Pérez-Sánchez
Jan 29, 2021·PloS One·Gustavo Ignacio Diaz-RubioRosa-Elena Navarro-Hernández
Jul 15, 2020·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Bogdan KolarzRafal Podgorski
Nov 3, 2020·Frontiers in Cell and Developmental Biology·Cristopher M RooneyPaul Emery
Feb 27, 2021·Experimental Neurobiology·So Yeong Cheon, Jong Eun Lee
Apr 4, 2021·International Journal of Molecular Sciences·Jinsha LiuSepideh Afshar
Jul 30, 2021·Advanced Drug Delivery Reviews·Amanda NashOmid Veiseh
Jan 8, 2022·The Journal of Applied Laboratory Medicine·John Koussiouris, Vinod Chandran

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
glycosylation

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