The role of anti-citrullinated protein antibody reactivities in an inception cohort of patients with rheumatoid arthritis receiving treat-to-target therapy

Arthritis Research & Therapy
Maria Karolina JonssonEspen A Haavardsholm

Abstract

Anti-citrullinated protein antibody (ACPA) reactivities precede clinical onset of rheumatoid arthritis (RA), and it has been suggested that ACPA reactivities towards distinct target proteins may be associated with differences in RA phenotypes. We aimed to assess the prevalence of baseline ACPA reactivities in an inception cohort of patients with early RA, and to investigate their associations with disease activity, treatment response, ultrasound findings and radiographic damage. Disease-modifying antirheumatic drug (DMARD)-naïve patients with early RA, classified according to the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) criteria, were included in the ARCTIC trial and assessed in the present analysis. During follow up, patients were monitored frequently and treatment was adjusted according to a predetermined protocol, starting with methotrexate monotherapy with prednisolone bridging. Analysis of 16 different ACPA reactivities targeting citrullinated peptides from fibrinogen, alpha-1 enolase, vimentin, filaggrin and histone was performed using a multiplex chip-based assay. Samples from 0, 3, 12 and 24 months were analysed. Controls were blood donors with similar characteristics to the...Continue Reading

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References

Feb 14, 1998·The Journal of Clinical Investigation·G A SchellekensW J van Venrooij
Oct 2, 2004·Annals of the Rheumatic Diseases·E LindqvistT Saxne
Mar 20, 2010·Arthritis Research & Therapy·Ger Jm PruijnWalther J van Venrooij
Mar 4, 2011·Annals of the Rheumatic Diseases·Benjamin A FisherPatrick J Venables
Oct 15, 2011·Annals of the Rheumatic Diseases·Annemiek WillemzeLeendert A Trouw
Apr 17, 2012·The Journal of Clinical Investigation·Ulrike HarreGeorg Schett
Feb 5, 2013·Annals of the Rheumatic Diseases·Désirée van der HeijdeBernard Combe
Oct 3, 2014·The Journal of Rheumatology·Lillian BarraUNKNOWN CATCH Investigators
Oct 7, 2015·Arthritis Research & Therapy·Jurgen van HeemstDiane van der Woude
Jun 4, 2016·Arthritis Research & Therapy·Linda JohanssonSolbritt Rantapää-Dahlqvist
Aug 18, 2016·BMJ : British Medical Journal·Espen A HaavardsholmTore K Kvien

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Citations

Sep 24, 2019·Scandinavian Journal of Rheumatology·M K JonssonE A Haavardsholm
Dec 19, 2018·Frontiers in Medicine·Serena BugattiRoberto Caporali
Aug 18, 2021·Metabolomics : Official Journal of the Metabolomic Society·Jessica D Murillo-SaichMonica Guma

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Methods Mentioned

BETA
ELISA
ESR

Clinical Trials Mentioned

NCT01205854

Software Mentioned

R
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