The role of anti-core antibody response in the detection of occult hepatitis B virus infection

Clinical Chemistry and Laboratory Medicine : CCLM
Simona UrbaniMassimo Franchini

Abstract

Occult hepatitis B virus (HBV) infection is characterized by the presence of HBV DNA in serum and/or in the liver of patients negative for hepatitis B surface antigen (HBsAg). Occult infection may impact in several different clinical contexts including the risk of HBV transmission with transfusion or transplantation, and endogenous viral reactivation. The gold standard test for detection of occult infection is the amplification of HBV DNA. However, the serological assay for the long-lasting antibody response to the highly immunogenic HBV core antigen (anti-HBc) represents a qualified candidate as a surrogate for DNA amplification, or for increasing overall sensitivity when assessing the risk of occult hepatitis in peripheral blood. The risk of occult hepatitis associated with anti-HBc seropositivity has been demonstrated extensively, and the presence of antibody response to HBc can be considered a sentinel marker of occult HBV infection.

References

Jun 22, 1978·The New England Journal of Medicine·J H HoofnagleH J Zimmerman
May 1, 1991·Seminars in Liver Disease·J H Hoofnagle, A M Di Bisceglie
Dec 1, 1981·American Journal of Clinical Pathology·I K MushahwarL R Overby
Jan 1, 1995·Springer Seminars in Immunopathology·D R MilichT Maruyama
Dec 11, 1997·The New England Journal of Medicine·W M Lee
Jul 1, 1999·The New England Journal of Medicine·I CacciolaG Raimondo
Oct 16, 1999·British Journal of Haematology·J P AllainL M Williamson
Feb 3, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H MarusawaT Chiba
Nov 14, 2000·Journal of Medical Virology·P GrobI Mushahwar
Jun 26, 2001·Journal of Medical Virology·B WeberH Rabenau
Jun 30, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C BréchotP Paterlini-Bréchot
Jun 30, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H S Conjeevaram, A S Lok
Aug 2, 2002·The Lancet Infectious Diseases·Michael Torbenson, David L Thomas
Oct 4, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Santiago J Muñoz
Oct 29, 2002·The Journal of Biological Chemistry·Shiow-Yi ChenYan-Hwa Wu Lee
Jun 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Antonio Bertoletti, Carlo Ferrari
Dec 31, 2003·Gastroenterology·Teresa PollicinoGiovanni Raimondo
Mar 12, 2004·The New England Journal of Medicine·Don Ganem, Alfred M Prince
Sep 24, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Carla S CoffinTomasz I Michalak
Mar 15, 2005·Journal of Hepatology·Gerald Y MinukAntonio Giulivi
Apr 26, 2005·Transplantation Proceedings·T M De FeoUNKNOWN Collaborative Kidney, Liver and Heart North Italy Transplant Program Study Groups
Dec 13, 2005·Journal of Hepatology·Massimo PuotiGiampiero Carosi
Feb 8, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·I Chemin, C Trépo
Feb 8, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Delphine CougotMarie Annick Buendia
Apr 14, 2006·Alimentary Pharmacology & Therapeutics·D Mutimer
May 5, 2006·Seminars in Liver Disease·Henry Lik-Yuen Chan, Joseph Jao-Yiu Sung
Jun 8, 2006·Vox Sanguinis·L Comanor, P Holland

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Citations

Aug 31, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Jessica P HwangRohit Loomba
Aug 10, 2012·Journal of Immigrant and Minority Health·Fabio TramutoFrancesco Vitale
Apr 8, 2011·World Journal of Gastroenterology : WJG·Sara OcanaJose Luis Lledo
Apr 30, 2011·World Journal of Gastroenterology : WJG·Zeinab Nabil Ahmed Said
Aug 13, 2013·Archives of Virology·So-Young KangWoo-In Lee
Mar 28, 2013·Hepatitis Research and Treatment·Mehdi Zobeiri
Sep 26, 2013·BioMed Research International·Fabio TramutoFrancesco Vitale
Jan 15, 2013·Critical Reviews in Oncology/hematology·Mario MandalàFausto Roila
Sep 25, 2012·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Ali Khamesipour, Reza Jafari Shakib
Feb 19, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Naoko TsubouchiHirohito Tsubouchi
Apr 15, 2016·Infection·C SagnelliE Sagnelli
Jun 25, 2015·Revista Da Sociedade Brasileira De Medicina Tropical·Mohamed MandourNashaat Hawass
Sep 2, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Marion MucheSeema Baid-Agrawal
Jun 7, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Shan-Shan WuWei Wang
Mar 5, 2015·Nephro-urology Monthly·Amitis RamezaniArezoo Aghakhani
Oct 1, 2020·Memórias do Instituto Oswaldo Cruz·Nédio MabundaIlesh Jani
Jul 16, 2017·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Shinji ItohYoshihiko Maehara
Dec 30, 2014·World Journal of Hepatology·Min-Sun Kwak, Yoon Jun Kim
Jan 14, 2021·Virology Journal·Camilla Rodrigues de Almeida RibeiroVanessa Salete de Paula

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