The role of anti-cyclic citrullinated peptide antibody in periodontal disease

International Journal of Immunopathology and Pharmacology
A BalliniF R Grassi

Abstract

The anti-Cyclic Citrullinated Peptide Antibodies (anti-CCP) are produced locally in the inflamed synovium of Rheumatoid arthritis (RA) patients, suggesting that citrullinated proteins are located in the inflamed synovium. In scientific literature were find periodontal bacterial DNA in serum and synovial fluid of RA with PD patients. RA and adult periodontitis share common pathogenetic mechanisms and immunologic and pathological findings RA. One oral pathogen strongly implicated in the pathogenesis of periodontal disease (PD), Porphyromonas. gingivalis, possesses a unique microbial enzyme, peptidylarginine deiminase (PAD), the human equivalent of which has been identified as a susceptibility factor for RA. Under this point of view, we speculate about the presence of anti-CCP antibodies in sera of PD with RA patients. We conducted this study to evaluate and compare the diagnostic and predictive utility of anti-CCP antibodies in patients with PD and patients with PD and RA. Anti-CCP antibody was not found in 21 sera (U/ml<10), included RA controls, while only 1 patient with chronic PD and probing depth of 7,1 mm was identified positive for anti-CCP (22.2 U/ml). Our data do not support a role for anti-CCP in diagnoses of periodonta...Continue Reading

References

Jan 1, 1997·Annual Review of Pharmacology and Toxicology·D J Stuehr
Nov 30, 2000·Arthritis Research·W J van Venrooij, G J Pruijn
Feb 24, 2001·Arthritis and Rheumatism·C C Reparon-SchuijtC L Verweij
Feb 21, 2003·Journal of Periodontology·Takahisa Imamura
Jun 1, 1939·The Biochemical Journal·W R Fearon
Feb 17, 2007·Journal of Molecular Biology·Reinout RaijmakersGer J M Pruijn
Nov 26, 2009·Journal of Clinical Periodontology·Rita E Martinez-MartinezJuan Pablo Loyola-Rodríguez

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Citations

Oct 31, 2012·Journal of Periodontology·Ceilidh MarchantP Mark Bartold
May 7, 2020·International Journal of Environmental Research and Public Health·Francesco InchingoloIoannis Alexandros Charitos
Jun 21, 2020·Biology·Andrea BalliniFrancesco Inchingolo
Apr 23, 2020·International Journal of Environmental Research and Public Health·Gianna Maria NardiBiagio Rapone
Mar 7, 2019·The Journal of Craniofacial Surgery·Vito CrincoliFiliberto Mastrangelo
Aug 20, 2021·Odontology·Steeve BregaintAnne Jolivet-Gougeon

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