The role of anti-myosin antibodies in perpetuating cardiac damage following myocardial infarction

International Journal of Cardiology
Tom J O'DonohoeNatkunam Ketheesan

Abstract

Recent improvements in the medical and surgical management of myocardial infarction mean that many patients are now surviving with greater impairment of cardiac function. Despite appropriate management, some of these patients subsequently develop pathological ventricular remodelling, which compounds their contractile dysfunction and can lead to congestive cardiac failure (CCF). The pathophysiological mechanism underpinning this process remains incompletely understood. One hypothesis suggests that a post-infarction autoimmune response, directed against constituents of cardiac myocytes, including cardiac myosin, may make an important contribution. Our review summarises the current literature related to the formation and clinical relevance of anti-myosin antibodies (AMAs) in patients with myocardial infarction. This discussion is supplemented with reference to a number of important animal studies, which provide evidence of the potential mechanisms underlying AMA formation and autoantibody mediated cardiac dysfunction.

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Citations

Sep 20, 2016·Journal of cardiology·Tom J O'DonohoeRyan G Schrale
Jun 21, 2017·Proceedings of the National Academy of Sciences of the United States of America·Xiaoyang LiHongjie Dai
Aug 11, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Lea KeppnerGustavo Ramos
Jun 14, 2020·ESC Heart Failure·Gerardo García-RivasGuillermo Torre-Amione
Jul 5, 2017·Chemical & Pharmaceutical Bulletin·Atsushi MaharaTetsuji Yamaoka
Apr 25, 2020·Frontiers in Immunology·Marcus J WagnerSadia Mohsin
Jan 29, 2019·Frontiers in Cardiovascular Medicine·Icia Santos-ZasHafid Ait-Oufella
Aug 28, 2021·Cardiovascular Research·Florentina PorschChristoph J Binder

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