PMID: 6965717Apr 1, 1980Paper

The role of antibodies directed against double-stranded DNA in the manifestations of systemic lupus erythematosus in childhood

The Journal of Pediatrics
T J LehmanK King

Abstract

The specificity of antibodies directed against dsDNA for SLE in a childhood population was tested by analyzing sera from 62 children with lupus and 283 children with other known or suspected autoimmune diseases. The role of these antibodies in the manifestations of SLE was then examined by correlating dsDNA Ab titer with clinical manifestations in 311 sera from 20 children followed for a mean of 51 months. Antibodies to dsDNA were found to be highly specific for SLE. The presence of antibodies in titers of 1:80 or greater correlated with the presence of active disease, arthritis, and rash, but not with azotemia, proteinuria, or increasing proteinuria; this indicated that their role in the induction of lupus nephritis was different from that in the induction of rash and arthritis. This may be due to a requirement for small immune complex formation during times of antigen excess in the initiation of lupus nephritis.

References

Mar 1, 1979·Arthritis and Rheumatism·A J SwaakT E Feltkamp
Feb 1, 1966·Arthritis and Rheumatism·E M Tan, H G Kunkel
Sep 1, 1973·Arthritis and Rheumatism·P G Natali, E M Tan
Sep 25, 1969·The New England Journal of Medicine·T PincusN Talal

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Citations

Jan 1, 1992·Annals of the Rheumatic Diseases·C K Ting, K H Hsieh
Jun 1, 1989·The Journal of Pediatrics·T J LehmanA Kovalesky
Jul 13, 2004·BMC Pediatrics·Julie L McGheeJames N Jarvis
Nov 1, 2008·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Takako MiyamaeShumpei Yokota
May 20, 1998·Journal of Molecular Recognition : JMR·C J WorkmanE W Voss
Aug 18, 2004·Pediatrics International : Official Journal of the Japan Pediatric Society·Kouichi YoshidomeYoshifumi Kawano
Apr 1, 1982·Pediatric Annals·N F Rothfield
May 1, 1990·Clinical Immunology and Immunopathology·M M WardD S Pisetsky
Jul 25, 2021·International Journal of Molecular Sciences·James Greenan-BarrettCoziana Ciurtin

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