The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplants

The Journal of Clinical Investigation
S S LinJ L Platt

Abstract

Long-term success in xenotransplantation is currently hampered by acute vascular rejection. The inciting cause of acute vascular rejection is not yet known; however, a variety of observations suggest that the humoral immune response of the recipient against the donor may be involved in the pathogenesis of this process. Using a pig-to-baboon heterotopic cardiac transplant model, we examined the role of antibodies in the development of acute vascular rejection. After transplantation into baboons, hearts from transgenic pigs expressing human decay-accelerating factor and CD59 underwent acute vascular rejection leading to graft failure within 5 d; the histology was characterized by endothelial injury and fibrin thrombi. Hearts from the transgenic pigs transplanted into baboons whose circulating antibodies were depleted using antiimmunoglobulin columns (Therasorb, Unterschleisshein, Germany) did not undergo acute vascular rejection in five of six cases. Biopsies from the xenotransplants in Ig-depleted baboons revealed little or no IgM or IgG, and no histologic evidence of acute vascular rejection in the five cases. Complement activity in the baboons was within the normal range during the period of xenograft survival. In one case, ac...Continue Reading

References

Dec 1, 1990·Immunology Today·J L PlattF H Bach
Dec 1, 1988·Transplantation·S MiyagawaH Kitamura
Nov 1, 1966·Transplantation·R J Perper, J S Najarian
May 1, 1970·The Journal of Experimental Medicine·N C Pedersen, B Morris
Jul 1, 1966·Transplantation·R J Perper, J S Najarian
Dec 1, 1995·The Journal of Experimental Medicine·S SaadiJ L Platt
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M S SandrinI F McKenzie
Nov 1, 1995·The Journal of Clinical Investigation·J C MageeJ L Platt
Jan 1, 1993·Blood Purification·A du MoulinR Spaethe
Aug 1, 1996·Immunology Today·W ParkerJ L Platt
Aug 1, 1996·Immunology Today·F H BachS C Robson
Sep 1, 1996·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·R PretagostiniR Cortesini
Sep 1, 1964·Annals of Surgery·K REEMTSMAO CREECH

❮ Previous
Next ❯

Citations

Jul 2, 2003·Microsurgery·Sonja SchrepferHermann Reichenspurner
Oct 10, 2007·Veterinary Research Communications·E CozziE Ancona
Apr 1, 2004·The Surgical Clinics of North America·Ruediger Hoerbelt, Joren C Madsen
Mar 27, 2001·Transplantation Proceedings·B J HolmesE Cozzi
May 20, 1999·Transplantation Proceedings·J L Platt
Aug 14, 2003·Molecular Immunology·Tom E Mollnes, Arnt E Fiane
Jun 20, 2002·Veterinary Immunology and Immunopathology·Jan HolgerssonLena Serrander
Sep 29, 1999·Immunology Today·M P SoaresF H Bach
Sep 28, 2000·Current Opinion in Immunology·J S Logan
Aug 16, 2002·Transplant Immunology·Anja Roos, Mohamed R Daha
Dec 22, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·D K CooperUNKNOWN Xenotransplantation Advisory Committee of the International Society for Heart and Lung Transplantation
Apr 3, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Martin J GoddardJohn Wallwork
Feb 15, 2000·The British Journal of Surgery·B SoinP J Friend
Jan 8, 2000·Clinical and Experimental Pharmacology & Physiology·J S Logan, A Sharma
Feb 15, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·A J TectorJ I Tchervenkov
Jan 30, 2007·Reproduction, Fertility, and Development·Gábor VajtaZoltán Macháty
Mar 16, 2005·DNA and Cell Biology·Luyang YuLihe Guo
Apr 7, 2005·DNA and Cell Biology·Luyang YuLihe Guo
Feb 24, 2001·Transplantation·W ParkerJ L Platt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.