PMID: 6166061Apr 1, 1981Paper

The role of antifibrinolytic therapy in the preoperative management of recently ruptured intracranial aneurysms

Surgical Neurology
B Guidetti, A Spallone

Abstract

In a retrospective study of the use of antifibrinolytic therapy in a series of patients with recently ruptured intracranial aneurysms, 131 patients were selected based on the following criteria: commencement of therapy within 3 days of the last subarachnoid hemorrhage (SAH); continuation of therapy for at least 6 days; and apparently uncomplicated surgery. Two main modalities of antifibrinolytic therapy were used: Group A, tranexamic acid (AMCA) 3 gm daily plus aprotinin k.i.u. (kallikrein inactivating units) daily (82 cases); Group B, AMCA 6 gm daily (41 cases). The remaining 8 patients were treated with epsilon-aminocaproic acid alone or in combination with aprotinin and were not considered to constitute a large enough group for statistical comparison. The rest of the preoperative treatment consisted of bed rest; mild sedation; antihypertensives, if the blood pressure exceeded 160 mm Hg; and osmotic diuretics as needed. The mean interval between last SAH and operation was about 13 days in both groups. The rates of rebleeding and thromboembolism were similar in the two groups but the rates of ischemic complications and post-SAH hydrocephalus were higher in Group B. The difference in the rate of severe cerebral ischemic complic...Continue Reading

Citations

Jan 1, 1987·Journal of Neurology·K W Lindsay
Mar 1, 1985·Italian Journal of Neurological Sciences·A Spallone
Apr 4, 2008·Neurocritical Care·Mark ChwajolE Sander Connolly
Sep 16, 1978·British Medical Journal·R S Maurice-Williams
Feb 1, 1980·Journal of Neurology, Neurosurgery, and Psychiatry·R S Maurice-WilliamsA Sykes
Jun 21, 2003·Journal of Neurosurgery·James D PalmerFausto Iannotti
Mar 22, 2002·The Journal of Pharmacology and Experimental Therapeutics·Roman FurtmüllerHeinz Redl
Jun 10, 2000·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·P P MasciP J Gaffney

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.