The role of antigen presenting cells in multiple sclerosis.

Biochimica Et Biophysica Acta
Emily M L ChastainStephen D Miller

Abstract

Multiple sclerosis (MS) is a debilitating T cell mediated autoimmune disease of the central nervous system (CNS). Animal models of MS, such as experimental autoimmune encephalomyelitis (EAE) and Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD) have given light to cellular mechanisms involved in the initiation and progression of this organ-specific autoimmune disease. Within the CNS, antigen presenting cells (APC) such as microglia and astrocytes participate as first line defenders against infections or inflammation. However, during chronic inflammation they can participate in perpetuating the self-destructive environment by secretion of inflammatory factors and/or presentation of myelin epitopes to autoreactive T cells. Dendritic cells (DC) are also participants in the presentation of antigen to T cells, even within the CNS. While the APCs alone are not solely responsible for mediating the destruction to the myelin sheath, they are critical players in perpetuating the inflammatory milieu. This review will highlight relevant studies which have provided insight to the roles played by microglia, DCs and astrocytes in the context of CNS autoimmunity.

References

Aug 23, 1984·Nature·G H WongJ W Schrader
Aug 1, 1993·Journal of Neuroscience Research·M E Smith
Nov 1, 1993·Journal of Neuroscience Research·K WilliamsJ P Antel
Jul 1, 1994·Journal of Neuroscience Research·K WilliamsJ McLaurin
Jan 1, 1997·Autoimmunity·N Wheatcroft, A P Weetman
Jul 28, 1999·International Immunology·H G Fischer, A K Bielinsky
Dec 2, 1999·Journal of Neuroimmunology·N Abdel-HaqW D Lyman
Jan 22, 2000·The Journal of Clinical Investigation·G C SuvannavejhS D Miller
May 18, 2000·Journal of Neuroimmunology·A CornetR S Liblau
Feb 27, 2001·Brain : a Journal of Neurology·M PashenkovH Link
Sep 25, 2001·Neuroreport·S TakeshitaD M Klinman
Oct 12, 2001·Glia·F Aloisi
Oct 12, 2001·Glia·Y Dong, E N Benveniste
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·K GoudyM A Atkinson
Aug 6, 2002·Journal of Neuroimmunology·Gaby ReichmannHans-Georg Fischer
Jun 24, 2003·Immunity·Gabriel L SicaLieping Chen
Oct 22, 2003·Journal of the Neurological Sciences·Jifen LiMalek Kamoun
Nov 13, 2004·Glia·Pamela A CarpentierStephen D Miller
Jan 18, 2005·Journal of Neuroimmunology·Cinthia FarinaEdgar Meinl
Jan 25, 2005·Nature Medicine·Frank L HeppnerAdriano Aguzzi
Mar 1, 2005·Nature Medicine·Eileen J McMahonStephen D Miller
Mar 11, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tim MagnusHeinz Wiendl

❮ Previous
Next ❯

Citations

Dec 21, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Takekazu KuboToshihide Yamashita
Apr 6, 2013·Neuroscience Bulletin·Li Cao, Cheng He
Apr 23, 2013·Nature Medicine·Yichuan XiaoShao-Cong Sun
Mar 12, 2013·Antioxidants & Redox Signaling·Djordje Miljković, Ivan Spasojević
Jun 27, 2012·Brain : a Journal of Neurology·Gurman KaurLars Fugger
Dec 29, 2011·Neurology Research International·Zhen Gao, Stella E Tsirka
Jun 24, 2011·The Journal of Clinical Endocrinology and Metabolism·Samantha KimballJodie M Burton
Jun 28, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rory D SpenceRhonda R Voskuhl
Mar 11, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yoichi KondoIan D Duncan
Feb 22, 2014·Apoptosis : an International Journal on Programmed Cell Death·Barbara KleinHubert H Kerschbaum
Mar 22, 2014·Cell and Tissue Research·Ori Staszewski, Marco Prinz
Jul 11, 2013·Clinical & Developmental Immunology·Tobias Goldmann, Marco Prinz
May 6, 2014·Journal of Neuroimmunology·Soomin ShinGregory F Wu
May 23, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Giuseppina Mattace RasoRosaria Meli
Aug 2, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Megan Strachan-WhaleyV Wee Yong
Oct 11, 2015·Biochimica Et Biophysica Acta·Marc-André LécuyerAlexandre Prat
Feb 14, 2016·Journal of Neurology·Marc Fakhoury
Mar 30, 2011·FEBS Letters·Djordje MiljkovićMarija Mostarica Stojković
Sep 6, 2011·FEBS Letters·Manuel B GraeberMichael L Rodriguez
Dec 3, 2014·Journal of Neuroinflammation·Hugo González, Rodrigo Pacheco
Jun 5, 2012·Journal of Theoretical Biology·K B Blyuss, L B Nicholson
Mar 29, 2011·Neurologic Clinics·Gregory F Wu, Enrique Alvarez
May 11, 2015·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Róisín M McManusMarina A Lynch
Oct 15, 2013·Glia·Jorge Ivan AlvarezAlexandre Prat
Jul 3, 2015·Brain, Behavior, and Immunity·Nuria Álvarez-SánchezAntonio Carrillo-Vico
Aug 5, 2015·Seminars in Immunopathology·Anat Shemer, Steffen Jung
Mar 23, 2011·The Mount Sinai Journal of Medicine, New York·Sridhar BoppanaSuhayl Dhib-Jalbut
Jun 26, 2012·Immunological Reviews·Lior MayoHoward L Weiner
Aug 21, 2013·Immunological Reviews·Daniel R GettsStephen D Miller
Oct 4, 2015·Trends in Immunology·Anat ShemerMarco Prinz
Mar 31, 2015·Brain Research·Luokun Xie, Shao-Hua Yang
Sep 9, 2015·Frontiers in Neurology·Jorge Correale, Mauricio F Farez
Aug 9, 2015·Neuroscience Bulletin·Peizhou Liang, Weidong Le

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Blood Brain Barrier & Cytokines

Some cytokines are able to cross the blood brain barrier through transport systems and enter the cerebrospinal fluid and interstitial fluid spaces. Here is the latest research on cytokines crossing the blood brain barrier and how this can affect tissues within the CNS.