PMID: 9526901Apr 4, 1998Paper

The role of antileukotrienes in asthma management

Current Opinion in Pulmonary Medicine
R A Tan

Abstract

The antileukotriene agents are the first new category of asthma medications introduced in the past two decades. Leukotriene synthesis inhibitors block the production of leukotrienes whereas leukotriene receptor antagonists block the effects of leukotrienes at the receptor level. Leukotriene synthesis inhibitors are further classified as either 5-lipoxygenase inhibitors or 5-lipoxygenase-activating protein inhibitors. Zafirlukast, montelukast, and pranlukast are leukotriene receptor antagonists whereas zileuton is a 5-lipoxygenase inhibitor. Antileukotrienes have been shown to be relatively safe and effective in chronic mild to moderate asthma. Studies are ongoing to determine how they compare with inhaled steroids, which remain the drug of choice for anti-inflammatory therapy.

Citations

Mar 29, 2002·Current Allergy and Asthma Reports·Stephen M Parnes
Aug 19, 2003·Current Opinion in Otolaryngology & Head and Neck Surgery·Steven M Parnes
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Steven M Parnes
Jul 1, 2002·Medical Journal, Armed Forces India·Girish GuptaC G Wilson
Nov 2, 2011·Therapeutic Advances in Respiratory Disease·Erkan VuralkanBerrak Ocal
Jun 1, 2000·Indian Journal of Pediatrics·G Gupta
Jan 5, 2002·Expert Opinion on Pharmacotherapy·Steven M Parnes
Feb 5, 2003·Bioorganic & Medicinal Chemistry Letters·Taracad K VenkatachalamFatih M Uckun

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