PMID: 19949756Dec 2, 2009Paper

The role of antimicrobial therapy for treatment of uncomplicated skin and soft tissue infections from community-acquired methicillin-resistant Staphylococcus aureus in children

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
Ching Shen TengChih-Chien Wang

Abstract

Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections in skin and soft tissues are increasing in children in Taiwan. This study investigated the outcomes of therapy with or without appropriate antibiotics among children with CA-MRSA skin and soft tissue infections (SSTIs), and analyzed the outcomes of management among children with Panton-Valentine leukocidin (PVL)-positive strains and PVL-negative strains. In this retrospective study, data for CA-MRSA SSTIs from 107 children younger than 18 years were analyzed. Worsening infection or other surgical therapy were considered treatment failure. Antimicrobial therapy was considered appropriate if it included at least 1 agent to which the organisms showed in vitro susceptibility. The rate of successful treatment was 90.7% (97 episodes). Eighty six children (80.4%) underwent incision and drainage as part of their initial therapy. Four of 5 children (80%) treated with an appropriate antibiotic initially were treated successfully, compared with 93 of 102 children (91.2%) who did not receive an appropriate antibiotic agent (p = 0.394; Fisher's exact test). Treatment failed for 5 of the 39 patients (12.8%) with PVL-positive SSTI CA-MRSA compared with only 1 ...Continue Reading

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