The Role of APOE in the Occurrence of Frontotemporal Dementia in Amyotrophic Lateral Sclerosis

JAMA Neurology
A ChiòA Calvo

Abstract

Amyotrophic lateral sclerosis (ALS) is a heterogeneous disease with a wide spectrum of involvement of cognitive functions. The mechanisms of this heterogeneity are still largely unknown, but genetic variants may account for this variability. To assess the influence of the apolipoprotein E (APOE) and C9ORF72 genotypes on cognitive impairment in a population-based series of Italian patients with ALS. All 504 patients with ALS living in Piemonte, Italy, diagnosed between January 1, 2009, and December 31, 2013, and identified through the Piemonte and Valle d'Aosta register for ALS, were eligible to participate in the study. Controls were 223 age- and sex-matched individuals identified through the patients' general practitioners. Data analysis was performed from June 1 to December 31, 2014. The presence of APOE and C9ORF72 genotypes was assessed. Patients were cognitively classified as having ALS with normal cognition, ALS with frontotemporal dementia (FTD), ALS with executive or nonexecutive impairment, and ALS with behavioral impairment. Of the 504 patients with incident ALS, 357 (70.8%) were included in the study; 154 were women, 203 were men, they had a mean (SD) age at onset of 64.8 (10.2) years, and 37 of them carried a C9ORF7...Continue Reading

Citations

Jan 6, 2017·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Michael J StrongMartin R Turner
Dec 17, 2016·Expert Review of Neurotherapeutics·P A McCombeR D Henderson
Oct 29, 2017·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Sali M K FarhanMichael J Strong
Sep 22, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A CanosaA Chiò
Jan 10, 2020·Annals of Neurology·Linjing ZhangDongsheng Fan
Feb 2, 2020·Molecular Neurodegeneration·Tosha WilliamsParamita Chakrabarty
Jun 28, 2019·Neurology·Carmel Armon, Bryan J Traynor
Apr 26, 2019·Frontiers in Neurology·Jose-Luis González De Aguilar
Feb 11, 2021·Journal of Neurology, Neurosurgery, and Psychiatry·Tianmi YangHuifang Shang
Jul 20, 2021·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Di HeLiying Cui
Aug 5, 2021·The Journal of Cell Biology·Wan Yun HoShuo-Chien Ling

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