The role of apoptosis, cell proliferation index, bcl-2, and p53 in glioblastoma prognosis

Arquivos de neuro-psiquiatria
Marlise de Castro RibeiroArlete Hilbig

Abstract

Glioblastoma is the most common neuroectodermic tumor. It is also the most malignant one. Many genetic changes are found in glioblastomas, among them, the presence of oncoproteins p53 and blc-2, as well as a high mitotic level and the presence of apoptosis. The utility of such findings through immunohistochemistry for the prognosis of patients remains uncertain. Our objectives in this study were to verify the presence of apoptosis, blc-2, p53, and the proliferative index (MIB-1), through immunohistochemistry, in 30 glioblastomas obtained by surgical resection between August 2000 and August 2001, as well as correlations between those immunohistochemical variables and the patient's age and survival time. Correlations between immunohistochemical variables themselves were also examined. For correlation calculations, Pearson's and Spermann's correlations were used and the time of survival was calculated with the Kaplan-Meier method. No correlation was found between immunohistochemical variables and survival time. There was also no correlation between those variables and the patients' age. A moderate inverse correlation was found between the apoptotic index (AI) and the mitotic index (MI) (p = 0.058), besides an inverse correlation b...Continue Reading

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Apr 22, 2005·Acta Neuropathologica·Matthias PreusserJohannes A Hainfellner
Jan 29, 2011·Cancer Letters·Günter Eisele, Michael Weller
Feb 24, 2015·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Matthew N T ThuyKatharine J Drummond
Nov 6, 2013·Antimicrobial Agents and Chemotherapy·Kelly C KatoFrédéric Frézard
Sep 18, 2017·Analytical and Bioanalytical Chemistry·Edwin OstertagRudolf W Kessler
May 13, 2010·Journal of Neuro-oncology·Georgia LevidouPenelope Korkolopoulou

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