The Role of APP O-Glycosylation in Alzheimer's Disease.

Biomolecules
Keiko Akasaka-Manya, Hiroshi Manya

Abstract

The number of people with dementia is increasing rapidly due to the increase in the aging population. Alzheimer's disease (AD) is a type of neurodegenerative dementia caused by the accumulation of abnormal proteins. Genetic mutations, smoking, and several other factors have been reported as causes of AD, but alterations in glycans have recently been demonstrated to play a role in AD. Amyloid-β (Aβ), a cleaved fragment of APP, is the source of senile plaque, a pathological feature of AD. APP has been reported to undergo N- and O-glycosylation, and several Polypeptide N-acetylgalactosaminyltransferases (ppGalNAc-Ts) have been shown to have catalytic activity for the transfer of GalNAc to APP. Since O-glycosylation in the proximity of a cleavage site in many proteins has been reported to be involved in protein processing, O-glycans may affect the cleavage of APP during the Aβ production process. In this report, we describe new findings on the O-glycosylation of APP and Aβ production.

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Citations

Mar 4, 2021·Mass Spectrometry Reviews·Jarne PauwelsKris Gevaert
Sep 14, 2021·Analytical Methods : Advancing Methods and Applications·Zheng GaoJunjie Ou

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Methods Mentioned

BETA
glycosylation
X-ray

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