PMID: 2508125Jan 1, 1989Paper

The role of arachidonate metabolites in ocular inflammation

Progress in Clinical and Biological Research
P Bhattacherjee

Abstract

PGs and leukotrienes are said to be mediators of various aspects of inflammation. In the rabbit eye, PGs are primarily involved in vasodilation and at least in rabbits, disruption of the blood-aqueous barrier. These effects vary qualitatively in different species. In the responses of the eye to chemical, mechanical, or neurogenic injury, PG involvement is limited, as indicated by the fact that cyclooxygenase inhibitors do not totally abrogate the responses. Inflammation, whether in the eye or in other tissues, is more complex than the injury responses. Complement pathway, arachidonate metabolites, cytokines, and monokines are major components in inflammation, but not necessarily in the response of tissues to injury. Topical or intracameral administration of leukotriene B4 causes PMN chemotaxis without affecting the blood-aqueous barrier. Peptidoleukotrienes such as leukotriene C4 and D4, on the other hand, are not chemotactic, but they do increase the permeability of the conjunctival microvasculature. Cyclooxygenase and 5-lipoxygenase products have been detected in the anterior chamber during the course of experimentally induced ocular inflammation and in humans with uveitis, but whether their presence is incidental or causal i...Continue Reading

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