The role of arachidonic acid/cyclooxygenase cascade, phosphodiesterase IV and Rho-kinase in H2 S-induced relaxation in the mouse corpus cavernosum

Pharmacological Reports : PR
Fatma Aydinoglu, Nuran Ogulener

Abstract

Penile corpus cavernosum is an extremely vascularized tissue and cavernosal smooth muscle tone is regulated by the balance between contractile and relaxant factor. We investigated the possible role of arachidonic acid/cyclooxygenase cascade, phosphodiesterase IV (PDEIV) and Rho-kinase in exogenous hydrogen sulfide (H2S)-induced relaxation in mouse corpus cavernosum. The relaxant response to H2S (NaHS as exogenous H2S; 1-1000μM) were obtained in isolated mouse corpus cavernosum tissues which pre-contracted by phenylephrine (5μM). The effects of 4-(4-octadecylphenyl)-4-oxobutenoic acid (OBAA; 10μM), a selective phospholipase A2 (PLA2) inhibitor, indomethacin (1μM), a non-selective cyclooxygenase (COX) inhibitor, baicalein (10μM), a lipoxygenase (LOX) inhibitor, and proadifen (10μM), cytochrome P450 inhibitor, on the relaxant responses to H2S were investigated. Furthermore, the effects of theophylline (500μM) and rolipram (1μM), a non-selective and selective PDEIV inhibitor, and fasudil (3μM), a specific Rho-kinase inhibitor, were studied on H2S-induced relaxation. H2S-induced relaxations were significantly reduced by OBAA, indomethacin and proadifen but not baicalein. Furthermore, theophylline, rolipram and fasudil reduced H2S-in...Continue Reading

References

May 13, 1998·British Journal of Clinical Pharmacology·P G BardinS T Holgate
Apr 27, 2002·British Journal of Pharmacology·Javier AnguloIñigo Sáenz De Tejada
Dec 25, 2003·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Takayuki MatsumotoKatsuo Kamata
Mar 27, 2004·World Journal of Urology·Stefan UckertChristian G Stief
Jun 12, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Youqin ChengRui Wang
Apr 19, 2005·Methods and Findings in Experimental and Clinical Pharmacology·R GuptaR Sunil Kumar
Apr 29, 2005·Biochemical Pharmacology·Cleber E TeixeiraR Clinton Webb
Jan 18, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Liming JinR Clinton Webb
Dec 16, 2006·The Journal of Clinical Hypertension·Arthur L Burnett
Jul 28, 2007·The Journal of Sexual Medicine·Balasubramanian SrilathaPhilip K Moore
Nov 22, 2007·The Journal of Pharmacology and Experimental Therapeutics·George D WebbPhilip K Moore
Feb 1, 2008·European Journal of Pharmacology·António José Santos-SilvaIgnacio Verde
Sep 13, 2008·American Journal of Physiology. Cell Physiology·Jia Jia LimJin-Song Bian
Mar 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Roberta d'Emmanuele di Villa BiancaGiuseppe Cirino
Apr 21, 2009·European Journal of Pharmacology·Ingeborg Dhaese, Romain A Lefebvre
Jul 17, 2009·Journal of Biochemistry·Norihiro ShibuyaHideo Kimura
Mar 2, 2010·Amino Acids·Hideo Kimura
Jul 17, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Mariarosaria BucciGiuseppe Cirino
Jan 14, 2011·The Journal of Pharmacology and Experimental Therapeutics·Roberta d'Emmanuele di Villa BiancaRaffaella Sorrentino
Feb 7, 2012·Biochemical Pharmacology·Mehdi GhasemiAli R Mani
Mar 2, 2012·The Journal of Sexual Medicine·Eginhard S WaldkirchPetter Hedlund
Dec 12, 2012·British Journal of Pharmacology·S RashidR E Roberts
Apr 5, 2013·The Journal of Sexual Medicine·Haocheng LinRun Wang
Dec 3, 2014·Nitric Oxide : Biology and Chemistry·Roberta d'Emmanuele di Villa BiancaRaffaella Sorrentino
Jan 9, 2015·American Journal of Physiology. Cell Physiology·Ancy D NalliKarnam S Murthy
Jun 28, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Ryan C JupiterPhilip J Kadowitz
Oct 24, 2015·The Journal of Pharmacology and Experimental Therapeutics·Elise R HedegaardUlf Simonsen
Jan 6, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Eda Karabal KumcuNuran Ogulener
Feb 5, 2016·Clinical and Experimental Pharmacology & Physiology·Fatma Aydinoglu, Nuran Ogulener

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.