PMID: 3747502Jul 1, 1986Paper

The role of aspirin and dipyridamole on vascular DNA synthesis and intimal hyperplasia following deendothelialization

The Journal of Surgical Research
Z S RadicP O Hagen

Abstract

Platelets are implicated both in acute thrombotic events and, through platelet-derived growth factor, in the development of intimal hyperplasia. We have investigated, in vivo, the influence of aspirin and dipyridamole on vascular smooth muscle cell proliferation and DNA synthesis following balloon catheter injury. Fifty-eight male, New Zealand white rabbits were divided equally into two groups; the test group was fed aspirin (14 mg/kg/day) and dipyridamole (9 mg/kg/day) from 2 days prior to surgery until sacrifice at 1, 2, 3, 4, 7, 14, or 28 days after injury. All animals were sacrificed 1 h after injection of [3H]thymidine and the smooth muscle cell DNA specific activity and total kinetic activity were determined. Intimal hyperplasia was measured by light microscopy and intimal nuclear proliferation was determined by counting nuclei per millimeter of internal elastic lamina. Nuclear proliferation was maximal at 14 days (25 +/- 1.2) but intimal hyperplasia was still increasing at 28 days. DNA specific activity after 24 hr (test: 4 +/- 2 dpm/micrograms DNA; control: 3.3 +/- 3 dpm/micrograms DNA) was similar to basal levels in uninjured rabbits. DNA synthesis peaked in both groups between the second and third day (test: 177 +/- 2...Continue Reading

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Citations

Jul 1, 1992·European Journal of Vascular Surgery·M EllisM K O'Malley
Dec 1, 1992·The Journal of Surgical Research·D EtonS S Ahn
Dec 1, 1996·Journal of the American College of Cardiology·H Le BretonE J Topol
Jan 1, 1996·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M IshikawaY Kubo
Jan 1, 1988·Annals of Vascular Surgery·W J Quiñones-BaldrichW S Moore
Dec 1, 1992·Hypertension·C L Jackson, S M Schwartz
Sep 1, 1989·The British Journal of Surgery·M K O'MalleyN J O'Higgins
Dec 1, 1992·The British Journal of Surgery·R VashishtM K O'Malley
Jan 1, 1990·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·R A YeagerR M Vetto
Mar 8, 2018·Journal of Neurointerventional Surgery·Jildaz CaroffAjit S Puri
Jan 1, 1996·The British Journal of Surgery·J D LowP E Norman
Mar 1, 1993·Annals of Vascular Surgery·B G RubinG A Sicard

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