The role of AT1 receptor-mediated reproductive function in renovascular hypertension in male rats

Hormones and Behavior
Karin Viana WeissheimerGilberto Luiz Sanvitto

Abstract

There is an association between hypertension and reproductive dysfunction. Angiotensin II (Ang II) is involved in the pathogenesis of hypertension and the regulation of reproduction. The present study aimed to determine whether the angiotensinergic system mediates the effects of hypertension on reproductive function in male rats subjected to a two-kidney, one-clip (2K1C) model. Sexual behavior parameters, gametogenesis and plasma concentrations of Ang II, testosterone, prolactin and corticosterone were evaluated in male rats 28days after 2K1C or sham surgery and losartan (Los) treatment (a type 1 angiotensin II (AT1) receptor antagonist) or vehicle (V) treatment. The animals were divided into Sham+V, 2K1C+V, Sham+Los and 2K1C+Los groups. The 2K1C+V group showed a hypertensive response, inhibition of sexual behavior, spermatogenesis dysfunction, and increases in plasma Ang II and prolactin. Conversely, plasma testosterone decreased, and plasma corticosterone remained constant. Losartan treatment normalized blood pressure and prevented the changes in plasma testosterone and prolactin, sexual behavior and spermatogenesis in the 2K1C+Los group. In addition, losartan treatment caused an additional increase in circulating Ang ll in b...Continue Reading

References

Jan 1, 1978·Annual Review of Physiology·I A ReidW F Ganong
Sep 1, 1978·Journal of Reproduction and Fertility·G W RobbG J Killian
Jan 1, 1991·European Urology·S C MüllerT F Lue
Apr 1, 1989·Seminars in Nuclear Medicine·T G Pickering
Jul 1, 1989·Endocrinology·K L Grove, R C Speth
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L M Plunkett, J M Saavedra
Jan 1, 1984·Neuroscience and Biobehavioral Reviews·F Drago
Jan 1, 1980·Reviews of Physiology, Biochemistry and Pharmacology·J T Fitzsimons
Jan 1, 1995·Neuroscience and Biobehavioral Reviews·W F Ganong
Jan 1, 1995·Clinical and Experimental Pharmacology & Physiology. Supplement·N ItohY Ohta
Jan 1, 1997·Brain Research Bulletin·P S MohankumarJ L Voogt
May 1, 1997·Brain Research. Brain Research Protocols·A Agmo
Jan 8, 1999·Regulatory Peptides·O von Bohlen und Halbach, D Albrecht
Feb 2, 1999·Pharmacology·P ChanJ T Cheng
Feb 4, 1999·Regulatory Peptides·R C SpethK L Grove
Apr 3, 1999·Neuropeptides·O von Bohlen und Halbach, D Albrecht
Oct 18, 2000·European Journal of Pharmacology·F Drago, C O Lissandrello
Apr 25, 2002·Hormones and Behavior·M K BreigeironG L Sanvitto
Dec 4, 2002·The Journal of Clinical Hypertension·Carlos M Ferrario, Pavel Levy
Jul 23, 2003·Journal of Human Hypertension·A Della ChiesaO M Hess
Oct 2, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Michael D Hendel, John P Collister
Feb 24, 2007·Life Sciences·Márcia Koja BreigeironGilberto Luiz Sanvitto
Jun 28, 2007·American Journal of Physiology. Endocrinology and Metabolism·Helge MüllerWalter Raasch
Jul 28, 2007·The Journal of Sexual Medicine·Giovanni CoronaMario Maggi
Sep 9, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Maria Maliszewska-ScisloNoreen F Rossi
Oct 16, 2008·Journal of Hypertension·Athanasios Manolis, Michael Doumas
Aug 21, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michelle WelshLee B Smith
Nov 7, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ruy R Campos
Dec 17, 2009·International Journal of Endocrinology·M K Gill-Sharma
Jul 27, 2010·The Journal of Reproduction and Development·Michiyo IshidaToshio Harigaya
Aug 4, 2010·Clinical and Experimental Pharmacology & Physiology·Ruy R CamposCássia T Bergamaschi
Sep 24, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alexandre A VieiraJohn P Collister

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Citations

Dec 3, 2014·European Journal of Pharmacology·Sobhana George Sugin Lal JabarisChidambaram Saravana Babu
Mar 19, 2014·Physiology & Behavior·Silvana JacobsGilberto L Sanvitto
Nov 5, 2020·International Journal of Hypertension·Veronica S de MatosJorge J de Carvalho

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