The Role of ATP-Binding Cassette Transporters in Neuro-Inflammation: Relevance for Bioactive Lipids.

Frontiers in Pharmacology
Gijs KooijHelga E de Vries

Abstract

ATP-binding cassette (ABC) transporters are highly expressed by brain endothelial cells that form the blood-brain barrier (BBB). These efflux pumps play an important role in maintaining brain homeostasis as they actively hinder the entry of unwanted blood-derived compounds into the central nervous system (CNS). Consequently, their high activity at the BBB has been a major hurdle for the treatment of several brain diseases, as they prevent numerous drugs to reach their site of action within the brain. Importantly, recent data indicate that endogenous substrates for ABC transporters may include inflammatory mediators, such as prostaglandins, leukotrienes, cytokines, chemokines, and bioactive lipids, suggesting a potential role for ABC transporters in immunological responses, and more specifically in inflammatory brain disorders, such as multiple sclerosis (MS). In this review, we will give a comprehensive overview of recent findings that illustrate this novel role for ABC transporters in neuro-inflammatory processes. Moreover, we will provide first insights into underlying mechanisms and focus on the importance for bioactive lipids, in particular platelet-activating factor, herein. A thorough understanding of these events may for...Continue Reading

Citations

Jan 17, 2014·Acta Neuropathologica·Gijs KooijHelga E de Vries
Dec 18, 2014·International Journal for Parasitology. Drugs and Drug Resistance·Robert M Greenberg
Nov 4, 2015·Biochimica Et Biophysica Acta·Melissa A Lopes PinheiroHelga E de Vries
May 2, 2015·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Dionna W WilliamsJoan W Berman
Oct 4, 2016·Frontiers in Molecular Neuroscience·Pekka PoutiainenAnna-Liisa Brownell
Feb 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wei ZhangXiaojun Wu
Jun 19, 2014·The Journal of Biological Chemistry·Elizabeth JaworskiFatah Kashanchi
Dec 2, 2017·Clinical and Experimental Immunology·M PazhouhandehF Rahimi Jamnani
Apr 23, 2020·Pharmacology & Therapeutics·Eva Gil-MartinsRenata Silva
May 1, 2021·International Journal of Molecular Sciences·Sweilem B Al RihaniVeronique Michaud
Apr 29, 2021·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Zhiqiang WeiXin Li
Apr 27, 2021·Frontiers in Neuroscience·Tomonori AikawaTakahisa Kanekiyo

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