The role of ATP-sensitive potassium channels in striatal dopamine release: an in vivo microdialysis study

Pharmacology, Biochemistry, and Behavior
T TanakaM Tanaka

Abstract

We used in vivo brain microdialysis to investigate the role of adenosine triphosphate (ATP)-sensitive potassium (KATP) channels in dopamine (DA) release regulated by DA autoreceptors in the rat striatum. Local infusions of the KATP channel opener nicorandil (10(-5)-10(-3) M) into the striatum through the dialysis membrane produced dose-dependent decreases in extracellular concentrations of DA. Local application of the D2 receptor antagonist (-)-sulpiride (SLP, 10(-5) M) or the KATP channel blocker quinine (QIN, 10(-3) M) produced significant increases in extracellular concentrations of DA. Nicorandil (10(-3) M) significantly blocked SLP (10(-5) M)- or QIN (10(-3) M)-induced increases in DA levels in the striatum. These results suggest that activation or inhibition of the KATP channel in the striatum causes decreases or increases, respectively, in endogenous DA release in vivo. Furthermore, SLP-induced increases in DA levels caused by blocking the tonic activation of DA autoreceptors are inhibited by the activation of KATP channels. These data suggest that striatal DA autoreceptors may inhibit DA release tonically by activating the KATP channel.

References

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Citations

Apr 16, 1998·European Journal of Pharmacology·M Y Li, M E Reith
Jul 1, 1997·Progress in Neuro-psychopharmacology & Biological Psychiatry·S Rosenzweig-LipsonJ E Barrett
Jul 3, 1999·Progress in Neuro-psychopharmacology & Biological Psychiatry·E MeririnneT Seppälä
Sep 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Marat V Avshalumov, Margaret E Rice
Sep 19, 2006·Neurochemistry International·Mirja SteinkampAndreas Moser
Oct 20, 2006·European Journal of Pharmacology·Mohammad-Reza Zarrindast, Sanaz Mohajeri
Oct 20, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Sarah L Milton, Howard M Prentice
Jul 15, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S L Milton, P L Lutz
Dec 9, 1998·The American Journal of Physiology·M Pék-Scott, P L Lutz

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